Principal Scientist, Medicinal Chemistry

Iambic; San Diego (CA); On-site; USD 152,000 - 190,000; Full time

Benefits offered by this job

Company paid healthcare

401K matching

Uncapped vacation

Job summary

Iambic Therapeutics seeks an experienced medicinal chemist to advance drug discovery in a highly collaborative setting. The role emphasizes lead optimization, multivariant SAR analysis, and interfacing with AI-driven molecular generation, property predictions and bioassay data generation.

This on-site position is based at our San Diego Headquarters. The candidate will work with AI/ML and computational chemistry teams to design novel molecules and propel programs from leads toward candidates,

Qualifications

• PhD/MS/BS in chemistry with a focus on synthetic organic chemistry.
• Experience in small molecule drug discovery in biotech/pharma settings.
• Proven track record of advancing programs from leads to candidates.

Responsibilities

• Devise strategies to identify lead molecules and optimize potency, selectivity, and ADME.
• Execute high-quality ideas using modern organic chemistry and parallel experimentation.
• Collaborate with biology, pharmacology, computational chemistry, ADME, and other functions.
• Influence computational methods and leverage high-throughput experimentation.
• Work with AI/ML teams to develop predictive models for new molecules.

Skills

Lead optimization

SAR analysis

Synthetic organic chemistry

Cross-functional collaboration

Project leadership

Computational chemistry collaboration

Education

PhD in chemistry

MS in chemistry

BS in chemistry

Job description

Job Summary

We seek an experienced and creative medicinal chemist with a proven track record of success in drug discovery. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting. The ideal candidate will be passionate about solving medicinal chemistry challenges, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation.

Job Summary

We seek an experienced and creative medicinal chemist with a proven track record of success in drug discovery. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting. The ideal candidate will be passionate about solving medicinal chemistry challenges, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation.
This position is on-site at our San Diego Headquarters.

Key Responsibilities

• Devise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis driven design principles.
• Execute on high quality ideas by employing a broad range of modern organic chemistry transformations, synthetic methods, creative use of parallel experimentations and implementing innovative techniques.
• Work closely with molecular and cellular biology, pharmacology, computational chemistry, ADME, and other key functions
• Influence the prospective use of computational methods and leverage automated synthesis and high-throughput experimentation capabilities
• Work closely with AI/ML teams to develop and implement relevant predictive models to aid in the design of new molecules
• Communicate project updates clearly and effectively to the broader team and key stakeholders
• Work as a member of the Chemistry research group and foster a culture of scientific excellence, innovation, and teamwork
  

Qualifications

• BS, MS, or PhD in chemistry with a focus on synthetic organic chemistry
• Experience in small molecule drug discovery in a biotechnology or pharmaceutical setting and a B.S. with 15+ years’ experience, M.S. with 12+ years’ experience or Ph.D. with 8+ years’ experience.
• Proven track record of success in advancing programs from leads to advanced candidates.
• Extensive experience in lead compound optimization for potency, selectivity, ADME and PK.
• Expert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patents
• Ability to integrate multiple R&D disciplines into a successful strategic project plan
• Experience working with computational chemists as part of project team in design of drug targets is required
• Strong interpersonal, communication, time management, and leadership skills
• Creative problem solving and management of relationships with several stakeholders within and beyond the company
  

About Iambic Therapeutics

Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.

Pay And Benefits

We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
Compensation Range: $152K - $190K