Bioanalytical Scientist - MS Assays & HitID

Iambic Therapeutics, Inc; California (MO); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Industry leading competitive pay

Company paid healthcare

Flexible spending accounts

Voluntary life insurance

401K matching

Uncapped vacation

Job summary

Iambic Therapeutics is seeking a Research Scientist in Bioanalytical Sciences & Assay Development to advance MS-based assays and screening workflows for HitID. The role supports ADME/DMPK characterization and physicochemical property assessment within a collaborative drug-discovery team.

The candidate will develop LC-MS/MS methods, enable high-throughput workflows, and work with biology, chemistry, DMPK, and AI teams to translate results into actionable insights.

Qualifications

• PhD in a relevant field with 0–5 years experience or an MS with significant industry experience.
• Strong foundation in mass spectrometry, bioanalytical science, and assay development.
• Experience developing, optimizing, and troubleshooting bioanalytical, biochemical, or screening assays.
• Interest in connecting experimental data with AI/ML-enabled drug discovery and molecular design.

Responsibilities

• Develop and implement MS-based assays and screening workflows for HitID, including ASMS and other MS-based approaches.
• Develop fit-for-purpose bioanalytical and biochemical assays supporting screening, hit confirmation, and compound characterization.
• Develop and execute in vitro ADME/DMPK assays, including metabolic stability, permeability, protein binding, and related endpoints.
• Develop physicochemical property assays, including solubility, logD/lipophilicity, ePSA, and related measurements.
• Develop automated and high-throughput assay workflows to improve capacity, turnaround time, and data quality.

Skills

Mass spectrometry

Bioanalytical science

Assay development

Data analysis

AI/ML interest

Education

PhD

MS + industry exp

Tools

LC-MS/MS

SCIEX

Agilent

Thermo

Job description

Iambic Therapeutics is seeking a Research Scientist in Bioanalytical Sciences & Assay Development to advance MS-based assays and screening workflows for HitID. The role supports ADME/DMPK characterization and physicochemical property assessment within a collaborative drug-discovery team.

The candidate will develop LC-MS/MS methods, enable high-throughput workflows, and work with biology, chemistry, DMPK, and AI teams to translate results into actionable insights.