Principal Scientist: In Vitro Selection & Display

RXinsider LTD.; Cambridge (MA); Hybrid; USD 143,000 - 257,000; Full time

Benefits offered by this job

Best-in-class healthcare coverage

Well-being resources

Family planning benefits

Generous paid time off

Job summary

Moderna is seeking a scientist to provide technical leadership for in vitro selection and cell-surface screening of viral and bacterial antigens. You will build high-throughput mammalian display systems and partner with computational design teams to evaluate designs at scale.

You will report to the Senior Director, Computational Design and In Vitro Selection, mentor scientists, and contribute to cross-functional discovery and platform discussions while advancing novel candidates toward the

Qualifications

• PhD in Immunology, Molecular Biology, Biochemistry, Protein Engineering or related field.
• 5+ years leading in vitro selection, mammalian cell-surface display, or directed-evolution.
• Demonstrated ability to drive complex screening campaigns end-to-end.

Responsibilities

• Lead execution of in vitro selection and cell-surface screening campaigns, providing technical leadership through experimental design and execution.
• Design and run high-throughput mammalian display campaigns for complex glycoproteins.
• Build and deploy scalable screening systems that replace resource-intensive plate-based assays.
• Develop and operationalize advanced in vitro selection and directed-evolution capabilities.
• Serve as a key experimental partner to computational design teams, generating datasets and feedback.
• Provide technical mentorship and scientific guidance to other scientists.
• Represent in vitro selection capabilities in cross-functional discussions.
• Mentor junior scientists to elevate design quality.

Skills

Technical leadership

Experimental design

In vitro selection

Mammalian display

Computational design workflows

Scientific independence

Education

PhD in Immunology, Molecular Biology, Biochemistry, Protein Engineering

Tools

Mammalian display systems

High-throughput screening

AI-driven protein design workflows

Job description

Moderna is seeking a scientist to provide technical leadership for in vitro selection and cell-surface screening of viral and bacterial antigens. You will build high-throughput mammalian display systems and partner with computational design teams to evaluate designs at scale.

You will report to the Senior Director, Computational Design and In Vitro Selection, mentor scientists, and contribute to cross-functional discovery and platform discussions while advancing novel candidates toward the