Lead Scientist, In Vitro Selection & Mammalian Display

BioSpace; Cambridge (MA); On-site; USD 143,000 - 257,000; Full time

Job summary

Moderna is seeking a Principal Scientist to provide technical leadership for in vitro selection and cell-surface screening of glycoprotein antigens. You will design and advance high-throughput mammalian display platforms and partner with computational design teams to refine candidates at scale.

You will mentor junior scientists, contribute to cross-functional discovery discussions, and help shape the integration of in vitro selection with AI- and structure-guided design across Moderna’s

Qualifications

• PhD in immunology, molecular biology, biochemistry or related field.
• 5+ years leading in vitro selection or mammalian display.
• Ability to drive complex screening campaigns end-to-end.

Responsibilities

• Lead execution of in vitro selection and cell-surface screening campaigns.
• Design and run high-throughput mammalian display campaigns.
• Build scalable screening systems replacing plate-based assays.
• Develop advanced in vitro selection and directed-evolution capabilities.
• Collaborate with computational design teams to generate datasets.
• Provide mentorship to other scientists.
• Represent in cross-functional discovery discussions.
• Mentor junior scientists to elevate design quality.

Skills

In vitro selection

Mammalian display

Directed evolution

Computational protein design

Leadership

Mentorship

Education

PhD in Immunology / Molecular Biology / Biochemistry

Tools

NGS data analysis

Bioinformatics workflows

Protein design software

Job description

Moderna is seeking a Principal Scientist to provide technical leadership for in vitro selection and cell-surface screening of glycoprotein antigens. You will design and advance high-throughput mammalian display platforms and partner with computational design teams to refine candidates at scale.

You will mentor junior scientists, contribute to cross-functional discovery discussions, and help shape the integration of in vitro selection with AI- and structure-guided design across Moderna’s