Principal Scientist, Early Discovery & Immune Cell Engineering

BeOne Medicines USA; San Carlos (CA); Presencial; USD 149.000 - 182.000; Jornada completa

Descripción de la vacante

BeOne Medicines USA in San Carlos, CA, seeks a Principal Scientist to lead early discovery programs within an agile biotech ecosystem. The role blends bench execution with matrix leadership to drive novel cell therapies and immunology platforms for oncology and IO/I&I indications.

The successful candidate will design and execute in vitro and ex vivo studies, guide cross-functional teams, and distill complex data into decision-ready packages while advancing BeOne's pipeline at the San Carlos site.

Formación

• Ph.D, M.D., or equivalent advanced degree in Immunology, Molecular Biology, Bioengineering, or a related scientific discipline with 5+ years of biotech/pharmaceutical industry experience.
• Hands-on expertise in molecular biology techniques and genetic modification of immune cells using viral and non-viral methods.
• Record of navigating drug discovery programs with milestone-driven data.
• Experience designing and executing complex cell-based immunology assays and navigating pooled or arrayed screens.

Responsabilidades

• Drive early discovery strategy by evaluating literature and guiding internal pipeline decisions.
• Advance immune cell engineering platforms to deliver novel therapies for oncology and immunology indications.
• Build, optimize, and deploy high-throughput screening platforms.
• Develop robust, quantitative cell-based immunology assays to characterize potency.
• Lead hands-on in vitro and ex vivo studies to generate data packages for decisions.
• Mentor scientists, lead matrix teams, and communicate findings clearly to stakeholders.

Conocimientos

Immunology

Molecular biology

Cell engineering

CRISPR/Cas9

Lentiviral methods

High-throughput screening

Data analysis

Leadership

Communication

Educación

Ph.D. or equivalent

Herramientas

IVT mRNA synthesis

Viral vectors (lentivirus)

Electroporation

CRISPR/Cas9

Transposons

Descripción del empleo

BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer.

General Description

Candidates must be able to work onsite in San Carlos, California.

At BeOne Institute, we extend BeOne's execution strength with a dedicated innovation engine, bringing agility and scientific depth to transform uncertainty into actionable and high-impact therapeutic opportunities. We operate according to three core principles:

• Bold exploration: we pursue novel and high-potential ideas through rapid, iterative innovation cycles.
• Strategic alignment: we prioritize disease areas that align closely with BeOne's R&D priorities and long-term vision.
• Pipeline impact: we translate insights into tangible assets and advance emerging platforms into impactful programs.

We are seeking a strategic and highly adaptive Principal Scientist to lead early discovery programs within our agile biotech ecosystem.

This role requires a unique blend of laboratory execution, matrix leadership, and a rigorous drug-development mindset. As a Principal Scientist, you will play a critical role in shaping BeOne's early discovery pipeline. Operating in a highly dynamic environment, you will help evaluate and determine our optimal therapeutic bets-whether that means developing a novel cell therapy platform, or identifying other high-potential modalities across Immuno-Oncology (IO) and Immunology & Inflammation (I&I). This position demands an individual who balances deep literature research with hands-on bench execution, possesses a collaborative spirit, and confidently brings independent, innovative hypotheses to the table.

Essential Functions of the Job

• Drive early discovery strategy, evaluate emerging scientific opportunities and literature to guide internal pipeline decisions.
• Advance immune cell engineering platforms to deliver novel cell therapies for oncology and immunology indications.
• Build, optimize, and deploy high-throughput screening platforms using pooled and arrayed approaches.
• Develop robust, quantitative cell-based immunology assays to characterize therapeutic potency.
• Lead hands-on execution of in vitro and ex vivo studies to generate decision-enabling data packages.
• Lead cross-functional matrix teams, collaborate with experts across the organization and mentor junior scientists to foster technical excellence, scientific rigor, and professional growth.
• Distill and present complex biological data packages
• Contribute to operational and management activities to support objectives at the San Carlos site.

Supervisory Responsibilities

May directly manage scientists and/or provide matrix leadership for project teams.

Requirements

Travel: No

• Ph.D, M.D., or equivalent advanced degree in Immunology, Molecular Biology, Bioengineering, or a related scientific discipline with 5+years of dedicated biotech or pharmacutical industry experience.
• Extensive, hands-on expertise in molecular biology (cloning, construct design, IVT mRNA synthesis) alongside deep proficiency in modifying primary immune cells using both viral (e.g., lentivirus) and non-viral (e.g., electroporation, CRISPR/Cas9, transposons) methodologies.
• A clear track record of navigating drug discovery programs. You prioritize actionable, milestone-moving data over open-ended academic exploration.
• Demonstrated success designing and executing complex cell-based immunology assays, as well as managing pooled or arrayed genetic/chemical screens.
• Proven experience successfully leading or driving progress within matrixed, multidisciplinary project teams in a fast-paced environment.
• Excellent oral and written communication skills with the confidence to challenge assumptions, debate technical strategies transparently, and introduce innovative concepts.

Preferred Qualifications

• A strong portfolio of peer-reviewed publications or patent filings in relevant areas of immunology, cell engineering, or oncology discovery.
• Demonstrated experience mentoring, training, or supervising junior scientists and research associates, fostering their technical growth.
• Hands-on experience working across multiple immune cell types (e.g., T cells, NK cells, macrophages, or B cells) rather than a single specific cell lineage.

Global Competencies

• Fosters Teamwork
• Provides and Solicits Honest and Actionable Feedback
• Self-Awareness
• Acts Inclusively
• Demonstrates Initiative
• Entrepreneurial Mindset
• Continuous Learning
• Embraces Change
• Results-Oriented
• Analytical Thinking/Data Analysis
• Financial Excellence
• Communicates with Clarity

Salary Range: $165,300.00 - $