Principal Scientist - Cancer Vaccines

BioSpace; Englewood (NJ); Vor Ort; USD 165.000 - 215.000; Vollzeit

Zusammenfassung

ICR is seeking a Principal Scientist to lead the Cancer Prevention Group, focusing on peptide-based and neoantigen cancer vaccines. The role will oversee preclinical design, execution, and interpretation, guiding translational progress to human studies.

Collaboration with CROs and external KOLs is essential to advance first-in-class preventive vaccine programs. The candidate should hold a PhD or MD with 10+ years in vaccine R&D, with deep expertise in cancer immunology, immuno-oncology, and

Qualifikationen

• PhD or MD with at least 10 years of vaccine development experience, preferably cancer vaccines.
• Strong expertise in personalized cancer vaccines and neoantigen-based strategies.
• Experience with vaccine epitope identification, selection, adjuvants, and immune monitoring.
• Proficiency in TCR repertoire analysis, cytokine release and ELISPOT assays.
• Ability to derive antigen-specific T cell clones/lines and work with external partners.

Aufgaben

• Lead ICR's Cancer Prevention Group in researching and developing preventive cancer vaccines.
• Drive end-to-end design, execution and interpretation of preclinical vaccine studies.
• Collaborate with external KOLs and CRO partners to translate findings into programs.

Kenntnisse

Vaccine development

Cancer immunology

Immuno-oncology

Peptide vaccines

Neoantigen research

T cell assays

ELISPOT

CRO management

T cell clones

Ausbildung

PhD

MD

Jobbeschreibung

ICR's Cancer Prevention science centers on developing preventive cancer vaccines. We are hiring a Principal Scientist with a deep background in peptide-based vaccine development, cancer immunology and immuno-oncology. As part of our mission to prevent age-related disease, training human immune systems to spot and destroy cancer before it becomes a problem is critical. We truly believe that an ounce of prevention is worth a pound of cure.

With Us, You'll Get To

• Lead ICR's Cancer Prevention Group in researching and developing novel preventive cancer vaccines
• Drive end-to-end design, execution and interpretation of preclinical vaccine studies, directly shaping the path to human translation
• Collaborate closely external KOLs and CRO partners to turn cutting-edge cancer immunology insights into first-in-class preventive vaccine programs

Please Apply If You Have

• A PhD, MD or both and at least 10 years of vaccine development experience, preferably cancer vaccines
• In-depth knowledge of and experience researching personalized cancer vaccines, including peptide-based vaccines and neoantigen-based cancer vaccines
• Extensive experience with vaccine epitope identification, selection/prioritization (of neoantigens), vaccine adjuvants and immune response monitoring
• Experience with molecular T cell receptor repertoire analysis and tracking, T cell proliferation assays, cytokine release assays and ELISPOT
• Experience deriving antigen-specific T cell clones and lines
• Expertise in cancer stem cell antigens, tumor-associated antigens, neoantigens, immuno-editing and immuno-monitoring
• Extensive knowledge of and experience with vaccine delivery systems, including peptide-, cell- and viral-based systems
• The ability to work well with CROs and manage external projects

Even if you don't meet all of these criteria, please apply anyway

And You'll Need

• The ability to work in the United States without sponsorship
• To have an easygoing, hard-working personality

Salary

• Starting base pay range: $165,000/yr - $215,000/yr
• Starting additional compensation range: $7,500/yr - $20,000/yr