Principal Scientist - Cancer Early Detection

BioSpace; Englewood (NJ); On-site; USD 165,000 - 215,000; Full time

Job summary

ICR seeks a Principal Scientist to lead the Cancer Early Detection Team, focusing on early-stage cancer detection through biomarker arrays and machine-learning-based prediction models. The role involves leading a cutting-edge biomarkers group and driving translatable pan-cancer screening initiatives.

Ideal candidates hold a PhD or MD with 10+ years in cancer research, strong Python programming skills, and deep knowledge of biostatistics and predictive ML methods.

Qualifications

• PhD or MD (or both)
• At least 10 years of cancer research experience, preferably in early detection and biomarkers
• Knowledge of pan-cancer screening, early detection, biomarkers, diagnostics, genetics, prevention and therapeutics
• Programming experience in Python
• Solid grasp of biostatistics and probability theory
• Experience with prediction modeling and machine learning using proper scoring rules

Responsibilities

• Lead a cutting-edge cancer biomarkers group focused on detecting cancer at the earliest stages
• Contribute practical and translatable pan-cancer screening/early detection ideas
• Quantify and track cancer biomarkers (CTCs, cfDNA, serum, plasma, urine proteins, RNA, metabolites, mutations, epigenetics)
• Collaborate with Biomarkers Team on molecular and cellular cancer prevention screening assays in a personalized medicine paradigm

Skills

Python

Biostatistics

Machine learning

Prediction modeling

Education

PhD or MD

Tools

Illumina NextSeq 550

Luminex

Kryptor

Access 2

Tecan

Job description

ICR's Cancer Early Detection program is focused on building early warning systems out of arrays of blood- and urine-based biomarkers from cancer patients and healthy controls, focusing on early stage cancers. We're using machine learning to predict cancer signatures to enable early intervention when cancer is most treatable. We're hiring a Principal Scientist to lead our Cancer Early Detection Team.

With ICR, You'll Get To

• Lead a cutting-edge cancer biomarkers group with the goal of detecting cancer at its earliest stages
• Contribute highly practical and readily translatable pan-cancer screening/early detection, diagnostic, prevention and therapeutic ideas
• Quantify and track cancer biomarkers, including CTCs, cfDNA, serum, plasma, and urine proteins, RNA, metabolites, driver-gene mutations, epigenetic modifications, etc
• Collaborate with ICR's Biomarkers Team to perform molecular and cellular cancer prevention screening assays, under a personalized medicine paradigm

Please Apply If You Have

• A PhD, MD or both
• At least 10 years of cancer research experience, preferably in early detection and biomarkers
• Current and in-depth knowledge of pan-cancer: screening, early detection, biomarkers, diagnostic prediction, genetics, prevention, and chemical and vaccine-therapeutics (practical and experimental)
• Programming experience in Python
• Solid grasp of biostatistics, especially probability theory
• Experience with prediction modeling and machine learning, including experience using proper scoring rules

Ideally, You'll Also Have

• Expert knowledge and understanding of worldwide cancer biomarker and detection assay development pipelines
• Experience with cell-based assays, immunofluorescent microscopy, qPCR, flow cytometry, single-cell genomics, RNAseq, cell culture, organoid culture, Illumina NextSeq 550, DNA methylation sequencing, ddPCR, Luminex, clinical chemistry instrumentation, Kryptor, Access 2, robotic liquid handling (e.g. Tecan), Vortex, and DepArray
• Experience with protein, RNA, and small metabolite cancer biomarker analysis

And You'll Need

• An easygoing, friendly personality
• The ability to work in the United States without sponsorship

Salary

Starting base pay range: $165,000/yr - $215,000/yr

Starting additional compensation range: $7,500/yr - $20,000/yr