Principal Scientist, Agentic Pipeline Strategy

Pioneering Intelligence; Cambridge (MA); On-site; USD 179,000 - 236,000; Full time

Job summary

Pioneering Intelligence, a Flagship Pioneering initiative, seeks a Principal Scientist to lead AI/ML-powered platforms for transformative therapies. You will codify clinical and commercial pipeline strategy and translate expert judgment into autonomous agentic capabilities.

The role blends deep translational medicine experience with frontier AI, collaborating with strategy analysts and PI engineers to prototype workflows and drive decisions across the enterprise.

Qualifications

• PhD or MD (or equivalent) in life sciences.
• Deep expertise in clinical and commercial pipeline strategy and drug development.
• Translational medicine experience through IND and Phase 1.
• Ability to distinguish legitimate patient needs from commercial framing.
• Familiarity with frontier AI tools and LLMs in practice.
• Comfort reading/writing code to prototype agentic workflows.
• Strong collaboration and senior leadership communication.
• Excellent analytical and problem-solving skills.

Responsibilities

• Serve as PI's in‑house subject‑matter expert on clinical and commercial pipeline strategy.
• Codify pipeline strategy into agentic systems and autonomous workflows.
• Own the legitimate patient need problem end‑to‑end with evaluations and ground truth.
• Prototype agentic capabilities: prompts, tools, and orchestration with engineering.
• Set technical and strategic direction for agentic capabilities across the ecosystem.
• Collaborate with business analysts to translate questions into agent specifications.
• Present progress and findings in research and product development forums.

Skills

AI/ML in life sciences

Pipeline strategy

Translational medicine

LLMs and agents

Agentic workflows

Tools

Python

Git

AWS

Job description

Pioneering Intelligence, a Flagship Pioneering initiative, seeks a Principal Scientist to lead AI/ML-powered platforms for transformative therapies. You will codify clinical and commercial pipeline strategy and translate expert judgment into autonomous agentic capabilities.

The role blends deep translational medicine experience with frontier AI, collaborating with strategy analysts and PI engineers to prototype workflows and drive decisions across the enterprise.