Principal Scientist, ADC Pharmacology & Strategy

Callio Therapeutics, Inc.; San Diego (CA); On-site; USD 156,000 - 176,000; Full time

Benefits offered by this job

Equity grant at hire

Comprehensive benefits

Job summary

Callio Therapeutics, Inc. in Seattle is seeking a Principal Scientist to lead pharmacology for novel dual-payload ADC projects. The role blends hands-on bench work (25–50%) with strategy development, project leadership, and oversight of external studies across Seattle, San Diego and Singapore.

The candidate will design experiments, manage CROs and vendors, and drive cross-functional data-driven decisions. A PhD with 5+ years or a Master’s with 8+ years is expected, with ADC discovery experience

Qualifications

• PhD in pharmacology, cell biology, cancer biology or related field with 5+ years industry experience preferred; Masters with 8+ years industry experience or equivalent education and experience.
• Experience with discovery ADC projects (in vitro and in vivo), preferably with novel payloads.
• Demonstrated high-impact publications and presentations to external audiences.
• Self-starter who thrives in lean, startup environments and can balance strategy with hands-on execution.
• Excellent written and verbal communication; able to work across time zones (Seattle/Singapore) with travel as needed.

Responsibilities

• Develop and manage pharmacology strategy to ensure data supports project decisions.
• Perform hands-on lab work (25-50%) focusing on in vitro/ex vivo ADC analysis and MOA characterization; design and troubleshoot assays.
• Manage external CROs, vendors, collaborators, and consultants through planning and reporting phases.
• Contribute as research expert on cross-functional project teams.
• Own project management for pharmacology deliverables: timelines, budgets, resources; proactively raise issues.
• Oversee multiple programs in a fast-paced, lean environment.

Skills

Communication skills

Self-starter

Project leadership

Education

PhD in pharmacology or related field

Masters in related field with 8+ years experience

Job description

Callio Therapeutics, Inc. in Seattle is seeking a Principal Scientist to lead pharmacology for novel dual-payload ADC projects. The role blends hands-on bench work (25–50%) with strategy development, project leadership, and oversight of external studies across Seattle, San Diego and Singapore.

The candidate will design experiments, manage CROs and vendors, and drive cross-functional data-driven decisions. A PhD with 5+ years or a Master’s with 8+ years is expected, with ADC discovery experience