Director, ADC & DAC Programs (Conjugate Lead)

Pinetree Therapeutics, Inc; Cambridge (MA); On-site; USD 180,000 - 250,000; Full time

Benefits offered by this job

Equity participation

Job summary

PineTree Therapeutics in Cambridge, MA, seeks a Director of ADC & DAC to lead end-to-end conjugate programs. This role focuses on defining linker‑payload and conjugation strategy, aligning with IND‑enabling activities, and guiding cross‑functional teams to technical milestones.

The candidate will bring deep expertise in linker chemistry and bioconjugation, with a track record of advancing ADC/conjugate programs and inventing innovative IP across payload classes.

Qualifications

• PhD in related discipline and 10+ years of biotech/pharmaceutical ADC experience.
• Proven track record advancing ADC/conjugate programs from design to IND-enabling development.
• Hands-on expertise in linker chemistry and site-specific conjugation across payload classes.
• Ability to lead cross-functional programs to concrete deliverables.

Responsibilities

• Own the ADC/DAC effort as single point of accountability for PineTree's conjugate programs.
• Define integrated linker–payload and conjugation strategy from feasibility to IND‑enabling development.
• Contribute to program prioritization, timelines, and go/no‑go decisions.

Skills

Independent leadership

Linker chemistry

Conjugation methods

Payload class knowledge

Education

PhD in synthetic organic chemistry

Job description

PineTree Therapeutics in Cambridge, MA, seeks a Director of ADC & DAC to lead end-to-end conjugate programs. This role focuses on defining linker‑payload and conjugation strategy, aligning with IND‑enabling activities, and guiding cross‑functional teams to technical milestones.

The candidate will bring deep expertise in linker chemistry and bioconjugation, with a track record of advancing ADC/conjugate programs and inventing innovative IP across payload classes.