Principal MSAT Engineer – Cell Therapy Processes

Vertex Pharmaceuticals LLC; Boston (MA); Hybrid; USD 87,000 - 130,000; Full time

Benefits offered by this job

Annual bonus

Annual equity awards

On-site role

Job summary

Vertex Pharmaceuticals LLC in Boston, MA seeks a Process Development Engineering Principal Associate to lead MSAT activities for cell therapy products. You will support development-to-manufacturing transfers and lifecycle improvements, including change control, risk management, and collaboration with CDMOs.

The role emphasizes cross-functional leadership, regulatory contribution, and a focus on continuous improvement and commercial readiness, with on-site work five days a week and a strong Total

Qualifications

• PhD in Life Sciences, chemical engineering, or related discipline or master’s degree with minimum 2+ years of industry experience or bachelor’s degree with 4+ years of relevant industry experience.
• Hands on experience with Manufacturing Science and Technology (MSAT) investigation and change management.
• Experience with cell-gene therapy is preferred.

Responsibilities

• Lead MSAT triage, investigation, and change control as a functional area assessor.
• Manage timely deliverables with milestones, identify program risks and communication strategies.
• Contribute to regulatory submissions (IND, IMPD) and author supporting documents.
• Coordinate cross-functional activities to align scope, schedule and budget.
• Drive continuous improvement and lifecycle management for both clinical and commercial manufacturing.

Skills

Excellent communication

Collaborative relationships

Cell processing experience

Design Control and Risk Management

FMEA experience

MSAT/Cell/gene therapy experience

Organizational skills

Education

PhD in Life Sciences

Chemical engineering

Master's degree + 2+ years

Bachelor's degree + 4+ years

Job description

Vertex Pharmaceuticals LLC in Boston, MA seeks a Process Development Engineering Principal Associate to lead MSAT activities for cell therapy products. You will support development-to-manufacturing transfers and lifecycle improvements, including change control, risk management, and collaboration with CDMOs.

The role emphasizes cross-functional leadership, regulatory contribution, and a focus on continuous improvement and commercial readiness, with on-site work five days a week and a strong Total