Principal Manager, Clinical Operations Lead

Immatics US, Inc.; United States; À distance; USD 165 000 - 180 000; Plein temps

Avantages offerts par ce poste

Health, dental, and vision insurance

Vacation time

Paid holidays

Life insurance

Disability insurance

401(k) with employer match

Parental leave

Résumé du poste

Immatics US, Inc. is seeking a Principal Manager, Clinical Operations Lead to oversee US regional trials, manage CROs and vendors, and drive study execution from start‑up through delivery in a fast‑paced oncology program.

This fully remote role reports to the Associate Director, Clinical Asset Management. The ideal candidate has 7+ years in global clinical operations with leadership, vendor management, risk mitigation, and cross‑functional collaboration; mentoring CTMs, CRAs and CTAs while

Qualifications

• Bachelor’s degree in life science, nursing, or similar.
• 7+ years of global clinical operations leadership with trial oversight.
• Experience with vendor management and cross-functional study leadership.

Responsabilités

• Lead clinical trial execution and operational delivery from start‑up through delivery.
• Provide oversight of CROs, vendors, and partners to meet quality, timelines and budget.
• Serve as Clinical Operations leader for CTMs, CRAs and CTAs on assigned projects.
• Drive risk identification, escalation and mitigation planning across studies.
• Support start-up, site feasibility, enrollment and execution activities.
• Partner with Clinical Development, Regulatory, Safety, Biometrics, Supply Chain and vendors.
• Contribute to SOP development and process optimization initiatives.
• Mentor and coach junior Clinical Operations team members.

Connaissances

Clinical operations leadership

Vendor management

Cross-functional leadership

Study start-up

Risk management

Team mentoring

Analytical skills

Formation

Bachelor’s degree in life science

Master’s degree preferred

Description du poste

Join Immatics and shape the future of cancer immunotherapy; one patient at a time! Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting‑edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T‑cell therapies and TCR bispecifics.

Why Join Us? Innovative Environment: Help to pioneer advancements in cancer immunotherapy. Collaborative Culture: Be part of a diverse team dedicated to your professional growth. Global Impact: Contribute to therapies that make a lasting impact on patients globally.

Role Overview We are seeking a Principal Manager, Clinical Operations Lead to support our Clinical Operations team. The Clinical Operations Lead will be responsible for the oversight, execution, and operational management of US regional clinical trials in support of our clinical development programs. Reports to: Associate Director, Clinical Asset Management Location: US, Fully Remote Salary Range: $165,000 - $180,000

Basic Qualifications: Bachelor’s degree in life science, nursing, or similar 7+ years of demonstrated leadership of global clinical operations in the pharmaceutical or biotechnology industry including clinical trial oversight, vendor management, and cross‑functional study leadership

Preferred Qualifications: Master’s Degree, preferably in life science, nursing, or similar Noted experience in late phase or launch in oncology. Experience cell and/or gene therapy, or other complex biologic clinical development programs Demonstrated ability to drive process improvements and operational excellence initiatives Ability to understand and navigate complex clinical development processes and cross‑functional interdependencies and collaborate with stakeholders outside of Clinical Operations Strong analytical and problem‑solving skills with the ability to assess operational impact across broader cross‑functional environments Ability to operate effectively in a fast‑paced and evolving clinical research environment

In this role you will:

• Lead clinical trial execution and operational delivery across internal and external stakeholders from study start‑up through execution
• Provide oversight of CROs, vendors, and clinical trial partners to ensure quality, compliance, timelines, and budget objectives are achieved
• Serve as the Clinical Operations leader for the team of CTMs, CRAs and CTAs for each assigned project
• Drive risk identification, issue escalation, and mitigation planning across assigned studies
• Support study start up, site feasibility, enrollment, and operational execution activities
• Partner cross-functionally with Clinical Development, Regulatory, Safety, Biometrics, Supply Chain, Program Leadership and external vendors
• Contribute to SOP development, process optimization, inspection readiness, and operational excellence initiatives
• Mentor and coach junior Clinical Operations team members as applicable

What do we offer? At Immatics, we believe in investing in our team’s health, safety and well‑being. Here’s what you can expect if you join Immatics

Comprehensive Benefits:

• Competitive rates for Health, Dental, and Vision Insurance
• 4 weeks of vacation, granted up front each year and prorated for first and last year of employment.
• 12 company paid holidays
• 7 days of sick time
• 100% employer-paid life insuranceup to at 1x annual salary, up to one hundred thousand dollars
• 100% employer-paid short- and long-Term disability coverage
• 401(k) with immediate eligibilityand company match. The company will match 100% of your contributions up to 3% of your base salary for the first two years of employment, 4% for years 2-3 of employment, and up to 5% of your salary from the fourth year onward of continued employment.
• Partially paid parental leavefor eligible employees.
• Additional voluntary employee-paid benefits and services, including accident, hospital indemnity, and critical illness insurance, as well as identity theft protection and pet insurance.

Equal Employment Opportunity We are an equal opportunity employer and are committed to building a diverse and inclusive workplace. We consider all qualified applicants for employment without regard torace, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexualorientation, gender identity or expression, national origin, ancestry, age, marital status, disability, geneticinformation, veteran status, or any other status protected by applicable law.

Reasonable Accommodations We are committed to providing reasonable accommodations to individuals with disabilities and to applicants withsincerely heldreligious beliefs, practices, or observances.

Work Authorization Applicants mustbe authorized towork in the United States without the need for current or future sponsorship.

Pre-Employment Requirements Employment is contingent upon successful completion of a background check, referencechecksand pre‑employment drug screening, wherepermittedby applicable law. For certain roles,additionalscreenings such as a credit check or motor vehicle record review may berequired, where job‑related and consistent with business necessity.

We are committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting‑edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T‑cell therapies and TCR bispecifics.