Principal Genomic Safety Scientist – Base Editing

Precision Point; San Francisco (CA); On-site; USD 120,000 - 180,000; Full time

Job summary

Precision Point is seeking a Principal or Senior Scientist to lead off-target validation and specificity assessment for a CRISPR base editing platform. You will design and execute genome-wide specificity assays, analyze NGS data, and collaborate across cross-functional teams to advance programs toward IND enabling studies.

Level and title are flexible based on experience; you will mentor junior scientists and help build the genomic safety function while tracking emerging detection technologies

Qualifications

• PhD in molecular biology, genetics, genomics, or related field.
• 5+ years in genome editing for Senior Scientist level or 8+ years for Principal Scientist level.
• Direct work in off-target or specificity assessment.
• Experience with off-target detection assays (GUIDE-seq, CIRCLE-seq, etc.).
• Strong NGS data analysis and bioinformatics background.

Responsibilities

• Design, execute, and interpret off-target and genome-wide specificity assays.
• Lead NGS-based bioinformatics analysis of on/off-target editing events.
• Develop and validate assays for genomic safety ahead of IND submissions.
• Partner cross-functionally with protein engineering and other teams.
• Present data to stakeholders and contribute to regulatory documents.
• Mentor junior scientists and help build genomic safety function.
• Stay current with emerging off-target detection technologies.

Skills

CRISPR base editing

Off-target validation

Genome editing

NGS data analysis

Bioinformatics pipelines

Cross-functional collaboration

Scientific presentation

Mentoring

Education

PhD in molecular biology or related field

Tools

GUIDE-seq

CIRCLE-seq

Digenome-seq

Job description

Precision Point is seeking a Principal or Senior Scientist to lead off-target validation and specificity assessment for a CRISPR base editing platform. You will design and execute genome-wide specificity assays, analyze NGS data, and collaborate across cross-functional teams to advance programs toward IND enabling studies.

Level and title are flexible based on experience; you will mentor junior scientists and help build the genomic safety function while tracking emerging detection technologies