Principal Formulation Scientist (Remote)

Praxis Precision Medicines, Inc.; Northern (KY); Remote; USD 170,000 - 190,000; Full time

Benefits offered by this job

Medical/dental/vision

Life insurance

401(k) match

Stock incentives

Discretionary bonus

PTO & holidays

Job summary

Praxis Precision Medicines, Inc. is seeking a Principal Scientist, Formulation Development to lead drug product development from discovery through late-stage clinical development.

You will translate promising compounds into robust, phase-appropriate formulations and scalable manufacturing processes. The role combines hands-on leadership with collaboration across Discovery, CMC, Regulatory, and external partners, driving strategy and execution in an agile environment.

Qualifications

• PhD in pharmaceutical sciences, chemical or biochemical engineering, chemistry, or a related scientific discipline, with 8+ years of relevant industry experience.
• Deep understanding of physicochemical and biopharmaceutical properties and how they inform formulation and drug product design.
• Demonstrated experience leading formulation development and manufacturing process development from early-stage work through clinical supply.
• Strong scientific judgment and a track record of creative problem-solving in complex development environments.
• Excellent communication and interpersonal skills, with the ability to influence across functions and communicate directly and clearly.
• Highly organized, detail-oriented, and able to manage multiple priorities while maintaining a high bar for quality.
• Self-directed and comfortable making decisions, challenging assumptions, and taking ownership without waiting for direction.
• Brings curiosity, innovation, urgency, integrity, and confidence to the work and thrives in a fast-moving, entrepreneurial environment.

Responsibilities

• Lead formulation strategy across programs, representing Formulation/Pharmaceutical Development on CMC and multidisciplinary project teams and clearly communicating strategy, risks, tradeoffs, and recommendations.
• Design, oversee, and interpret formulation studies to characterize novel drug candidates, including small molecules and/or ASOs, and translate learnings into development decisions.
• Develop phase-appropriate formulations and manufacturing processes using sound formulation, material characterization, and pharmaceutical manufacturing principles.
• Partner with Discovery and other functions to provide timely, high-quality formulation support for preclinical studies and enable efficient progression into clinical development.
• Drive technical execution with CDMOs, providing scientific oversight for formulation and process development and ensuring external activities meet Praxis quality, timing, and clinical manufacturing needs.
• Author and contribute to technical and regulatory documents, including formulation development reports and CMC sections of INDs, IMPDs, NDAs, and related submissions.
• Influence and enable others by guiding scientists and external partners, bringing together cross-functional teams, and anticipating and resolving issues before they slow program progress.

Skills

Formulation development

Leadership

Cross-functional collaboration

Scientific judgment

Education

PhD in pharmaceutical sciences or related field

Job description

Praxis Precision Medicines, Inc. is seeking a Principal Scientist, Formulation Development to lead drug product development from discovery through late-stage clinical development.

You will translate promising compounds into robust, phase-appropriate formulations and scalable manufacturing processes. The role combines hands-on leadership with collaboration across Discovery, CMC, Regulatory, and external partners, driving strategy and execution in an agile environment.