Principal Clinical Scientist

Alignerr Corp.; Pittsburgh (Allegheny County); Remote; USD 138,000 - 248,000; Part time

Job summary

Alignerr is seeking a Principal Clinical Scientist to shape how real-world clinical data informs AI training and evaluation. This fully remote hourly contract role demands senior clinical expertise and regulatory acumen to ensure regulator-ready datasets.

You will design protocols, audit trial results, and assess AI-generated analyses for regulatory relevance, collaborating with world-leading AI teams. Flexible, asynchronous work supports experts who value rigorous science and impactful

Qualifications

• Senior clinical professional with hands-on experience designing clinical trial protocols for regulatory submission.
• Deep expertise interpreting clinical data for major regulatory agencies such as the FDA, EMA, or equivalent bodies.
• Strong grounding in clinical research methodology, biostatistics, or translational science.
• Detail-oriented and rigorous — you hold data to the highest standards of accuracy and scientific integrity.
• Comfortable working independently and asynchronously in a remote, task-based environment.

Responsibilities

• Design and review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training and evaluation
• Interpret and audit clinical trial results to ensure accuracy, consistency, and alignment with regulatory standards
• Evaluate AI-generated clinical analyses for scientific soundness and regulatory relevance
• Provide expert feedback that directly shapes how AI models reason about clinical trial data, outcomes, and methodology
• Apply your regulatory expertise — FDA, EMA, or equivalent — to validate the integrity of clinical data used in AI systems

Skills

Clinical trial design

Regulatory submissions

Biostatistics

FDA/EMA knowledge

Data interpretation

Tools

Clinical NLP tools

AI platforms

Job description

Principal Clinical Scientist (AI Training)

About The Role

What if your years of clinical trial expertise could directly influence how AI understands and evaluates real-world medical evidence? We're looking for a Principal Clinical Scientist to bring senior-level clinical knowledge into cutting-edge AI research workflows — helping ensure that the AI systems shaping the future of biomedicine are built on rigorous, regulatory-grade science.

This is a fully remote, flexible contract role designed for senior clinical professionals who want to do meaningful work at the intersection of clinical science and frontier AI.

• Organization: Alignerr
• Type: Hourly Contract
• Location: Remote
• Commitment: 10–40 hours/week

What You'll Do

• Design and review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training and evaluation
• Interpret and audit clinical trial results to ensure accuracy, consistency, and alignment with regulatory standards
• Evaluate AI-generated clinical analyses for scientific soundness and regulatory relevance
• Provide expert feedback that directly shapes how AI models reason about clinical trial data, outcomes, and methodology
• Apply your regulatory expertise — FDA, EMA, or equivalent — to validate the integrity of clinical data used in AI systems

Who You Are

• Senior-level clinical professional with hands-on experience designing clinical trial protocols for regulatory submission
• Deep expertise interpreting clinical data for major regulatory agencies such as the FDA, EMA, or equivalent bodies
• Strong grounding in clinical research methodology, biostatistics, or translational science
• Detail-oriented and rigorous — you hold data to the highest standards of accuracy and scientific integrity
• Comfortable working independently and asynchronously in a remote, task-based environment

Nice to Have

• Prior experience with data annotation, data quality review, or evaluation systems
• Background in AI-adjacent fields or health data science
• Experience reviewing or contributing to regulatory dossiers or clinical study reports
• Familiarity with clinical NLP tools or AI-assisted research platforms

Why Join Us

• Work directly on frontier AI systems making a real impact on clinical and biomedical research
• Fully remote and flexible — work when and where it suits you
• Freelance autonomy with the structure of meaningful, expert-level work
• Influence how AI understands, evaluates, and reasons about real-world clinical evidence
• Collaborate with world-leading AI research teams and labs
• Potential for ongoing work and contract extension as new projects launch