Principal Clinical Scientist

Alignerr Corp.; Sheffield (TX); Remote; USD 138,000 - 248,000; Part time

Job summary

Alignerr seeks a Principal Clinical Scientist to guide AI training with senior clinical trial expertise, ensuring regulatory-grade data underpinning biomedical AI. This fully remote hourly contract role involves designing regulator-ready protocols, auditing trial results, and providing expert feedback to improve AI reasoning, on a flexible schedule.

You will interpret clinical data for regulatory standards, identify gaps in AI reasoning, and contribute to setting standards for regulatory science

Qualifications

• Senior clinical scientist with hands-on experience designing clinical trial protocols for regulatory submission.
• Expert interpreter of clinical data for agencies such as the FDA, EMA, or equivalent regulatory bodies.
• Strong grounding in clinical research methodology, biostatistics, or translational science.
• Precise, rigorous thinker who can spot flawed reasoning or incomplete analysis quickly.
• Clear written communicator who can document feedback in structured, actionable formats.

Responsibilities

• Design and review clinical trial protocols used to generate high-quality, regulator-ready training datasets for AI systems.
• Interpret and audit clinical trial results to ensure accuracy, consistency, and alignment with regulatory standards.
• Evaluate AI-generated clinical analyses for scientific soundness and regulatory relevance.
• Identify gaps, errors, and weaknesses in how AI models reason about clinical evidence — and provide expert feedback to correct them.
• Help define what "good" looks like when AI tackles clinical trial data, outcomes, and methodology.
• Work independently and asynchronously on task-based assignments — on your own schedule.

Skills

Clinical trial design

Regulatory submission experience

Biostatistics

Clinical data interpretation

Regulatory affairs understanding

Job description

Principal Clinical Scientist (AI Training)

About The Role

What if your career spent designing rigorous clinical trials and interpreting regulatory-grade data could directly influence how AI reasons about medicine? We're looking for a Principal Clinical Scientist to bring senior-level clinical expertise into the development of cutting-edge AI systems — ensuring the models shaping the future of biomedical research are built on a foundation of scientific rigor.

This is a fully remote, flexible contract role. You won't be running trials or filing submissions — you'll be doing something arguably more consequential: teaching AI to think like a seasoned clinical scientist.

• Organization: Alignerr
• Type: Hourly Contract
• Location: Remote
• Commitment: 10–40 hours/week

What You'll Do

• Design and review clinical trial protocols used to generate high-quality, regulator-ready training datasets for AI systems
• Interpret and audit clinical trial results to ensure accuracy, consistency, and alignment with regulatory standards
• Evaluate AI-generated clinical analyses for scientific soundness and regulatory relevance
• Identify gaps, errors, and weaknesses in how AI models reason about clinical evidence — and provide expert feedback to correct them
• Help define what \"good\" looks like when AI tackles clinical trial data, outcomes, and methodology
• Work independently and asynchronously on task-based assignments — on your own schedule

Who You Are

• Senior clinical scientist with deep, hands‑on experience designing clinical trial protocols for regulatory submission
• Expert interpreter of clinical data for agencies such as the FDA, EMA, or equivalent regulatory bodies
• Strong grounding in clinical research methodology, biostatistics, or translational science
• Precise, rigorous thinker who can spot flawed reasoning or incomplete analysis quickly
• Clear written communicator who can document feedback in structured, actionable formats
• Self-motivated and reliable when working independently without direct supervision

Nice to Have

• Prior experience with data annotation, data quality evaluation, or AI training workflows
• Background in regulatory affairs, pharmacovigilance, or clinical operations
• Familiarity with AI tools or model evaluation platforms as an end user
• Experience in oncology, rare disease, or other complex therapeutic areas

Why Join Us

• Work on frontier AI systems alongside leading AI research labs — at the cutting edge of clinical and biomedical AI
• Fully remote and flexible — work when and where it suits you
• Freelance autonomy with the structure of meaningful, expert-level work
• Make a direct, lasting impact on how AI understands and evaluates real-world clinical evidence
• Influence the standards that define how AI models approach regulatory science
• Potential for ongoing work and contract extension as new projects launch