Principal Clinical Scientist

Alignerr; Austin (CO); Remote; USD 96,000 - 179,000; Full time

Job summary

Alignerr Corp. in the United States is seeking a Principal Clinical Scientist to bring senior clinical rigor to AI training and evaluation. You will collaborate with top AI research teams to ensure regulatory-ready data, analyses, and reasoning for frontier AI systems.

This fully remote, hourly contract role offers 10–40 hours per week and the chance to shape how clinical evidence informs AI at scale.

Qualifications

• Senior-level clinical scientist with hands-on trial protocol design for regulatory submission.
• Deep expertise interpreting clinical data and navigating regulatory expectations.
• Strong grounding in biostatistics and translational science.

Responsibilities

• Design and critically review trial protocols for regulator-ready AI training data.
• Interpret and audit clinical trial results for accuracy and regulatory alignment.
• Evaluate AI-generated analyses for scientific soundness and regulatory relevance.
• Provide structured feedback to improve AI model reasoning on trial data, endpoints, and outcomes.
• Help establish rigorous, trustworthy clinical AI standards in practice.

Skills

Clinical trial design

Regulatory submissions

Biostatistics

Translational science

Remote collaboration

Education

PhD in Clinical Science

Tools

AI evaluation tools

Job description

Principal Clinical Scientist (AI Training)

About The Role

What if your career-long expertise in clinical trial design and regulatory science could directly shape how AI reasons about medical evidence — influencing the systems that will define the future of biomedical research?

We're looking for a Principal Clinical Scientist to bring senior-level clinical rigor into the development of cutting-edge AI models. You'll work alongside world-leading AI research teams to ensure the clinical data, analyses, and reasoning embedded in frontier AI systems meet the standards expected in real-world regulatory submissions.

This is a fully remote, flexible contract role built for experienced clinical scientists who want to do meaningful work on their own terms.

• Organization: Alignerr
• Type: Hourly Contract
• Location: Remote
• Commitment: 10–40 hours/week

What You'll Do

• Design and critically review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training and evaluation
• Interpret and audit clinical trial results to ensure accuracy, internal consistency, and alignment with regulatory standards
• Evaluate AI-generated clinical analyses for scientific soundness, methodological integrity, and regulatory relevance
• Provide expert, structured feedback that directly improves how AI models reason about clinical trial data, endpoints, and outcomes
• Help establish the bar for what rigorous, trustworthy clinical AI looks like in practice

Who You Are

• Senior-level clinical scientist with hands‑on experience designing trial protocols for regulatory submission (FDA, EMA, or equivalent)
• Deep expertise interpreting clinical data and navigating the expectations of major regulatory agencies
• Strong grounding in clinical research methodology, biostatistics, translational science, or a related discipline
• Meticulous and structured in how you evaluate evidence — you notice when something doesn't hold up
• Able to communicate complex scientific judgments clearly and concisely in written form
• Comfortable working independently and asynchronously in a remote environment

Nice to Have

• Prior experience with data annotation, data quality frameworks, or AI evaluation workflows
• Background in pharmacovigilance, outcomes research, or health technology assessment
• Familiarity with AI tools or clinical informatics platforms

Why Join Us

• Work directly on frontier AI systems that are reshaping how clinical and biomedical research is understood and conducted
• Influence how AI evaluates, interprets, and communicates real-world clinical evidence at scale
• Fully remote and flexible — work when and where it suits you, with no fixed schedule
• Freelance autonomy with meaningful, intellectually rigorous work on every project
• Collaborate with leading AI research labs and clinical experts from around the world
• Potential for ongoing work and contract extension as new projects launch