Principal Clinical Scientist

Alignerr; Atlanta (GA); Remote; USD 138,000 - 248,000; Full time

Job summary

Alignerr is seeking a Principal Clinical Scientist to bring senior-level rigor to AI systems trained on clinical and biomedical data. This fully remote hourly contract role emphasizes regulator-ready data and strict scientific standards.

You will design and review trial protocols, audit results for regulatory relevance, and provide expert feedback to ensure AI models reason correctly about clinical evidence. This position offers flexible remote work and ongoing project potential.

Qualifications

• Senior clinical scientist with hands-on experience designing clinical trial protocols for regulatory submission (FDA/EMA and global bodies).
• Deep expertise interpreting clinical data for regulatory agencies and sponsors.
• Strong foundation in clinical research methodology, biostatistics, translational science.
• Comfortable working independently in an asynchronous, remote environment.

Responsibilities

• Design and review clinical trial protocols used to generate regulator-ready training datasets for AI systems.
• Interpret and audit clinical trial results to ensure accuracy and regulatory alignment.
• Evaluate AI-generated clinical analyses for scientific soundness and regulatory relevance.
• Provide expert, structured feedback to improve AI model reasoning on trial data, endpoints and outcomes.
• Help establish standards for good clinical reasoning at the frontier of AI development.

Job description

Principal Clinical Scientist (AI Training)

About The Role

What if your career-long expertise in clinical trial design and regulatory science could directly shape how AI understands and reasons about clinical evidence? We're looking for a Principal Clinical Scientist to bring senior-level rigor to one of the most consequential frontiers in modern technology: AI systems trained on clinical and biomedical data. Your expertise will help ensure that the AI models influencing the future of healthcare research are grounded in the same scientific standards expected by the FDA, EMA, and their global counterparts. This is a fully remote, flexible contract role built for experienced clinical scientists who want to contribute to something genuinely new – without leaving behind the discipline and precision that defines their work.

Key Details

• Organization: Alignerr
• Type: Hourly Contract
• Location: Remote
• Commitment: 10–40 hours/week

What You'll Do

• Design and review clinical trial protocols used to generate high-quality, regulator-ready training datasets for AI systems
• Interpret and audit clinical trial results to ensure accuracy, consistency, and alignment with regulatory standards
• Evaluate AI-generated clinical analyses for scientific soundness and regulatory relevance
• Provide expert, structured feedback that directly improves how AI models reason about clinical trial data, endpoints, and outcomes
• Help establish the bar for what good clinical reasoning looks like — at the frontier of AI development

Who You Are

• Senior clinical scientist with hands‑on experience designing clinical trial protocols for regulatory submission
• Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent global bodies
• Strong foundation in clinical research methodology, biostatistics, translational science, or a closely related discipline
• Naturally rigorous — you hold AI-generated outputs to the same standards you'd apply in a real submission context
• Comfortable working independently in an asynchronous, remote environment

Nice to Have

• Prior experience with data annotation, data quality evaluation, or AI output assessment
• Background in drug development, medical devices, or diagnostics
• Familiarity with clinical data standards such as CDISC, ICH guidelines, or GCP frameworks

Why Join Us

• Work directly on frontier AI systems with real impact on clinical and biomedical research
• Fully remote and asynchronous — work on your schedule, from anywhere
• Freelance autonomy combined with meaningful, substantive work
• Influence how AI understands, evaluates, and communicates real-world clinical evidence
• Collaborate with leading AI research teams and labs at the cutting edge of the field
• Potential for ongoing work and contract extension as projects evolve