Principal Clinical Data Manager

Worldwide Clinical Trials; Wilmington (NC); Remote; USD 99,000 - 196,000; Full time

Job summary

Worldwide Clinical Trials is seeking a Principal Clinical Data Manager to lead data management across global programs, ensuring quality and timely delivery. This role requires strategic oversight from start-up to database lock and collaboration with sponsors, vendors, and cross-functional teams.

You will mentor colleagues, drive process improvements, support audits, and contribute to business development activities. The role is remote for US-based candidates with global exposure.

Qualifications

• Bachelor’s degree or higher in biomedical sciences or related field, or equivalent experience.
• Minimum 7 years of clinical data management experience in pharmaceutical, biotechnology, or medical device industries.
• Expert knowledge of clinical data management best practices, technologies, and processes.
• Proven ability to independently lead and oversee complex global clinical data management projects.

Responsibilities

• Lead end-to-end clinical data management activities across multiple complex global projects and programs.
• Ensure data management deliverables, timelines, budgets, and resources are effectively planned and managed.
• Oversee development and review of key study documentation, including Data Management Plans and database specs.
• Direct user acceptance testing, data cleaning strategies, reconciliation activities, and database lock readiness.

Skills

Analytical thinking

Problem-solving

Decision-making

Communication skills

Interpersonal skills

English proficiency

Education

Bachelor’s degree or higher in biomedical sciences or related field

Job description

Join a global Contract Resource Organization (CRO) where innovation meets purpose. At Worldwide Clinical Trials, we're driven by a shared commitment to improving lives through high-quality clinical research. Our teams are empowered to think creatively, take ownership, and deliver meaningful work that helps bring life-changing therapies to patients around the world.

With more than 4,000 professionals across the globe, we foster a collaborative and inclusive environment where diverse perspectives are valued, growth is encouraged, and every contribution makes an impact. Whether you're building your career or bringing years of experience, you'll have the opportunity to learn, grow, and help shape the future of clinical research.

Make an Impact as a Principal Clinical Data Manager at Worldwide

As a Principal Clinical Data Manager, you'll play a critical leadership role in delivering high-quality clinical data across complex global programs. Your expertise will help ensure studies are executed efficiently, accurately, and on schedule while maintaining the highest standards of quality and sponsor satisfaction.

In this highly visible role, you'll provide strategic oversight of data management activities from study start-up through database lock, partnering with cross-functional teams, sponsors, and vendors to drive successful outcomes. You'll also serve as a subject matter expert, helping shape processes, mentor colleagues, and contribute to continuous improvement initiatives across the department.

Your leadership will directly support the integrity of clinical trial data, enabling informed decisions that advance research and development programs around the world.

Where You'll Work

This is a REMOTE role open to candidates based in US. You will collaborate with global teams across multiple time zones.

What You'll Do

• Lead end-to-end clinical data management activities across multiple complex global projects and programs.
• Ensure data management deliverables, timelines, budgets, and resources are effectively planned and managed.
• Oversee the development and review of key study documentation, including Data Management Plans, database specifications, edit checks, and data transfer agreements.
• Direct user acceptance testing, data cleaning strategies, reconciliation activities, and database lock readiness to ensure high-quality study data.
• Monitor study progress through metrics and proactively identify, communicate, and mitigate project risks and scope changes.
• Serve as the primary data management representative in internal and sponsor-facing meetings, providing expert guidance and leadership.
• Act as a subject matter expert for designated data management processes, driving process optimization, training, quality improvement, and CAPA activities.
• Mentor and support data management colleagues while contributing to departmental initiatives and operational excellence programs.
• Support business development activities, sponsor audits, inspections, and other key stakeholder engagements as needed.

What You'll Bring

• Bachelor's degree or higher in biomedical sciences, life sciences, computer science, or a related field, or equivalent relevant experience.
• Minimum 7 years of clinical data management experience or related experience within the pharmaceutical, biotechnology, or medical device industries.
• Expert knowledge of clinical data management best practices, technologies, and processes supporting clinical trials.
• Advanced understanding of clinical trial documentation and processes, including protocols, CRFs, statistical analysis plans, and study reports.
• Proven ability to independently lead and oversee complex global clinical data management projects.
• Strong analytical, problem-solving, and decision-making skills with exceptional attention to detail.
• Excellent communication and interpersonal skills with the ability to collaborate effectively across internal and external stakeholder groups.
• Proficiency in English.

Discover the Difference

We love knowing that someone is going to have a better life because of the work we do. Discover the Difference at Worldwide Clinical Trials. Explore additional opportunities on our careers page, visit http://www.worldwide.com/careers, or connect with us on LinkedIn.

At Worldwide Clinical Trials, we are committed to fostering an inclusive and equitable workplace by providing transparent compensation.

The salary range for this position is annually (For hourly paid positions, the stated salary range reflects hourly rates):

United States of America - $99,000.00 - $196,000.00

The salary range provided is intended to give candidates an understanding of potential earnings. Compensation will fall within the provided range, and it not a guarantee of exact salary. The final salary will be determined based on relevant experience, performance, education, and internal equity. In addition to base salary, we offer a competitive benefits package depending on location. We ensure pay equity and transparency and comply with all applicable labor laws. Salary information will be discussed during the interview process, and we encourage candidates to inquire about compensation at any stage.

Worldwide is an equal opportunity employer that is committed to enabling professionals from all backgrounds and experiences to succeed and, to that end, we prioritize attracting diverse talent and cultivating an inclusive environment that encourages collaboration and creativity. We know that when our employees feel appreciated and included, they can be more creative, innovative, and successful. We’re on a mission to hire the very best and are committed to creating exceptional employee experiences where everyone is respected and has access to equal opportunity. We provide equal employment opportunities to all employees and applicants regardless of race, color, ethnicity, ancestry, religion, national origin, gender, sex, gender identity or expression, sexual orientation, age, citizenship, marital or parental status, disability, military status, or other class protected by applicable law.

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