Prime Editing Scientist — Platform Tech & Innovation

Prime Medicine, Inc.

Cambridge (MA)

On-site

USD 131,000 - 146,000

Full time

14 days+

Get more replies from employers

Send a job-specific resume in minutes.

Benefits offered by this job

Health, dental, vision insurance

401(k) match with equity programs

Paid time off and wellness days

Job summary

Prime Medicine, Inc. is seeking an exceptionally driven Scientist to join the Platform Technology & Innovation team.

This hands-on role focuses on designing Prime Editing systems for new targets, advancing platform technologies, and translating discoveries into therapeutic strategies. Reporting to the VP of Platform Technology & Innovation, you will work across teams to drive program-specific solutions, mentor researchers, and contribute to publications and patents while maintaining rigorous

Qualifications

Ph.D. in Molecular Biology, Biochemistry, RNA Biology, Chemical Biology, or a closely related field; preferred additional 2+ years of relevant postdoctoral and/or drug discovery research experience.
Deep hands-on expertise in genome editing, prime editing, pegRNA design and screening, molecular biology, cell culture, and next-generation sequencing.
Experience working in a collaborative, cross-functional research environment with the ability to contribute meaningfully to team science while driving individual workstreams autonomously.
Experience applying computational tools or AI/ML approaches to protein engineering or pegRNA sequence design or optimization is a plus.
Experience translating genetic medicines therapeutic technologies from in vitro systems into in vivo animal models, using non-viral (e.g., LNP) or viral (e.g., AAV) delivery systems.
Working knowledge of human biology and animal models of disease as they relate to therapeutic development.
Excellent scientific communication skills, with the ability to present complex findings clearly to diverse audiences and contribute to written scientific outputs; strong publication and presentation record, with engagement in the broader scientific community (e.g., conferences, scientific societies).
Experience providing day-to-day scientific direction to research associates, interns, or co-op students, and comfort collaborating with and directing the work of external CROs; success operating within a lean, matrixed team, including dotted-line working relationships, is a plus.

Responsibilities

Design, construct, and systematically optimize Prime Editing approaches for new editing targets using in vitro cell culture systems initially and subsequently transitioning to in vivo development.
Design and execute well-controlled experiments to probe structure-function relationships in Prime Editing system components; generate clean, interpretable data that drives platform design decisions.
Partner with cross-functional teams (Computational Biology, Technical Development, and program teams) as well as external collaborators and CROs to translate platform advances into program-specific solutions, including supporting Development Candidate nominations.
Maintain active engagement with scientific literature and emerging technologies in genome editing, protein engineering, and therapeutic targets to anticipate the next wave of innovation and identify external advances or collaborations worth pursuing.
Communicate research findings clearly to internal scientific audiences; contribute to publications, patent filings, and conference presentations that advance Prime Medicine's scientific profile.
Adhere to all laboratory safety requirements and procedures; author, review, and maintain accurate laboratory notebooks.
Mentor and provide day-to-day scientific direction to research associates and interns/co-op students, with potential dotted-line oversight of additional staff as the team scales; contribute to a culture of scientific excellence, intellectual curiosity, and collaborative problem-solving.