Postdoctoral Scientist: Synuclein Neuroscience

BioSpace; Boston (MA); On-site; USD 58,000 - 123,000; Full time

Job summary

Lilly’s Neurodegeneration Biology group in Boston seeks a Postdoctoral Scientist to investigate α-synuclein biology, aggregation, and disease mechanisms. You will use physiologically relevant cellular models, including engineered cell lines and iPSC-derived neurons, to study aggregation and therapy-relevant questions.

The role blends protein biophysics, cell biology, and translational neuroscience, with opportunities to contribute to publications and internal collaborations.

Qualifications

• PhD in a relevant field (or nearing completion) with 6 months to graduation.
• Hands-on protein aggregation biochemistry experience, including ThT-based kinetic assays.
• Experience generating/engineering mammalian cell lines (CRISPR editing, lentiviral methods).
• Experience with recombinant protein expression and biochemical/biophysical characterization.

Responsibilities

• Define molecular/cellular drivers of α-synuclein aggregation and pathology.
• Develop scalable cellular models including iPSC-derived neurons.
• Perform ThT aggregation kinetics and kinetic modeling.
• Collaborate with team across Lilly Boston site and external partners.

Skills

Protein aggregation biochemistry

CRISPR editing

Lentiviral transduction

iPSC-derived neurons

Biophysical readouts

ThT-based assays

Education

PhD in cell biology/biochemistry/molecular biology/neuroscience/protein biophysics

Tools

Recombinant protein expression

Crosslinking mass spectrometry

Imaging (confocal/high-content)

Analytical ultracentrifugation

Job description

Lilly’s Neurodegeneration Biology group in Boston seeks a Postdoctoral Scientist to investigate α-synuclein biology, aggregation, and disease mechanisms. You will use physiologically relevant cellular models, including engineered cell lines and iPSC-derived neurons, to study aggregation and therapy-relevant questions.

The role blends protein biophysics, cell biology, and translational neuroscience, with opportunities to contribute to publications and internal collaborations.