Postdoctoral Research Associate - Epidemiology and Cancer Control

St. Jude Children's Research Hospital, Inc.; United States; On-site; USD 60,000 - 80,000; Full time

Benefits offered by this job

Excellent benefits

Job summary

St. Jude Children's Research Hospital invites a Postdoctoral Research Fellow to join the Epidemiology and Cancer Control lab.

The role centers on pharmacogenomics of long-term toxicities in childhood cancer survivors, leveraging whole-genome/exome data, RNA-seq, ATAC-seq, and multi-omics to uncover mechanisms and disparities. The candidate will possess a PhD in a quantitative field, a strong publication record, and coding skills in R/Python/C++.

Qualifications

• PhD or equivalent degree in genetics, epidemiology, biostatistics, bioinformatics, or a related quantitative field
• Strong publication record
• Strong research interests in genetic epidemiology, pharmacogenomics, statistical genetics, or population genetics and experience in statistical and computational analyses of high-throughput omics data
• Ability to code in one or more scientific programming languages (e.g., R, Python, C/C++)
• Excellent communication and writing skills.

Responsibilities

• Lead genetic epidemiology analyses for long-term cancer therapy outcomes in childhood survivors.
• Integrate multi-omics data to elucidate molecular mechanisms and health disparities.
• Collaborate with multidisciplinary teams and contribute to manuscripts and grants.

Skills

R programming

Python

C/C++

Genetic epidemiology

Pharmacogenomics

Statistical genetics

Population genetics

Omics data analysis

High-throughput data

Education

PhD in genetics, epidemiology, biostatistics, bioinformatics, or related field

Tools

RNA-seq analysis

ATAC-seq

Proteomics

Metabolomics

GCTA

PLINK

Job description

The Department of Epidemiology and Cancer Control is seeking a highly motivated Postdoctoral Research Fellow to join the laboratory of Dr. Yadav Sapkota. Successful candidates will work on projects related to pharmacogenomics of long-term toxicities of cancer therapy in childhood cancer survivors. This is a grant-funded position. Specific research topics for this role include 1) genetic association analyses (whole genome and whole exome sequence associations and polygenic risk scores) for various long-term health outcomes among survivors of European and African ancestries; 2) analyses of multi-omics (genomics, transcriptomics, proteomics, and metabolomics) and system genetics (e.g., eQTLs regulating molecular responses to cancer therapies in human induced pluripotent stem cells) data for elucidating molecular mechanisms for health outcomes; and 3) evaluating health disparities through pharmacogenomics. The candidate will have ample, immediate opportunities to work with large-scale whole genome and whole exome sequencing, RNA-seq, ATAC-seq, proteomics, and metabolomics data in a well-established cohort of childhood cancer survivors with clinically ascertained deep phenotyping of health outcomes at multiple time-points. S/he will work within a diverse, highly collaborative, and multi-disciplinary research environment and interact with world leaders in the fields of cancer survivorship, genetics, stem cell pharmacogenomics, epidemiology, biostatistics, and computational biology. The successful applicant will gain extensive training and experience in genetic epidemiology and pharmacogenomics, and computational and analytical skills with full access to cutting-edge tools/technologies and shared core facilities and resources. Grant-writing training opportunities and support are also available. St Jude Children's Research Hospital offers competitive salary, excellent benefits, and is an equal opportunity employer.

Position qualifications

• PhD or equivalent degree in genetics, epidemiology, biostatistics, bioinformatics, or a related quantitative field
• Strong publication record
• Strong research interests in genetic epidemiology, pharmacogenomics, statistical genetics, or population genetics and experience in statistical and computational analyses of high-throughput omics data
• Ability to code in one or more scientific programming languages (e.g., R, Python, C/C++)
• Excellent communication and writing skills.

We are committed to a human-centered hiring experience. Technology may support portions of our process, but recruiting decisions involve human review and engagement. Learn more about our approach to AI. St. Jude is an Equal Opportunity Employer.

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