Postdoctoral Fellow-MSH-32074-060

Mount Sinai; United States; On-site; USD 55,000 - 75,000; Full time

Job summary

Mount Sinai's Cardiovascular Research Institute in New York seeks a PhD-level researcher to study LVNC-associated MYH7 variants. The project uses engineered heart tissues and sequencing to uncover how variants affect motor activity and interact with other LVNC risk genes.

The candidate should have a PhD in Biomedical Science or related field and demonstrate high-level scholarship and technical expertise. Collaboration with the lab team is essential for advancing this genetic research.

Qualifications

• PhD in Biomedical Science or a closely related field.
• Evidence of high-level scholarship and related technical expertise.

Responsibilities

• Evaluate the performance of missense MYH7 variants associated with LVNC in engineered heart tissues.
• Use statistical genetics approaches to better understand the distribution of these variants in the population.
• Perform unbiased sequencing assays to link these variants to other known LVNC risk genes.

Skills

Statistical genetics

Sequencing assays

Biomedical research

High-level scholarship

Education

PhD in Biomedical Science

Tools

Sequencing tools

Job description

Department: Cardiovascular Research Institute

Physical work location: 1470 Madison Ave, Hess Bldg, 7th Fl, New York, NY 10029

Name PI or Supervisor: Tanner O. Monroe PhD, [e-mail], 210-861-7888

Web link to Lab: https://drtomonroe.github.io

Web link to Department: https://icahn.mssm.edu/research/cardiovascular

Administrative Contact: Christopher Chan PhD, [e-mail],212-824-9897

Details of Research Project:

The predominant myosin heavy chain expressed in human heart, beta-MyHC, is encoded by the MYH7 gene. MYH7variants are well described in hypertrophic cardiomyopathy and less frequently seen in dilated cardiomyopathy. A recent series of publications link variants in the 5’ end of the MYH7 gene as implicated in left ventricular noncompaction cardiomyopathy, often in the setting of a dilated ventricle with impaired function. Importantly, premature truncations as well as missense variation within the MYH7 gene has been linked to LVNC in both population studies and in individuals and families. We hypothesize that specific missense variants identified in LVNC are associated with reduced contractility, rather than hyperdynamic MYH7 variants seen in hypertrophic cardiomyopathy. Additionally, many missense variants in MYH7 are considered variants of uncertain significance and methods such as those being used here may help adjudicate variants of risk.

Technical Duties:

The candidate will evaluate the performance of missense MYH7 variants associated with LVNC in engineered heart tissues, use statistical genetics approaches to better understand the distribution of these variants in the population, and perform unbiased sequencing assays to link these variants to other known LVNC risk genes.

Educational and other Requirements for the position:

PhD in Biomedical Science or a closely related field

Experience Required:

Evidence of high-level scholarship and related technical expertise

Goals/Outcomes of the Research Project:

The goal is to better understand how these LVNC-MYH7 variants influence the motor activity of beta-MyHC and to spur further investigations linking sarcomeric LVNC to other genetic risk mediators for the condition.