Postdoctoral Fellow-MSH-30025-251

Mount Sinai; United States; On-site; USD 65,000 - 90,000; Full time

Benefits offered by this job

Mentorship

State-of-the-art technologies

Career development support

Scientific independence

Job summary

Mount Sinai is seeking an independent scientist to design and execute cancer biology research integrating organoid and mouse models with single-cell genomics. The lab emphasizes mentorship and interdisciplinary collaboration in a cutting-edge environment.

The candidate will contribute to manuscripts and grant applications while advancing a program at the interface of cancer biology, epigenetics, stem cell biology, and genomics.

Qualifications

• Ph.D. in Cancer Biology, Molecular Biology, Genetics, Epigenetics, Stem Cell Biology, or a related field.
• Strong publication record or evidence of research productivity.
• Ability to work independently and collaboratively.
• Experience with molecular biology and mammalian cell culture.

Responsibilities

• Design and execute independent research projects.
• Perform experiments using organoid, cell culture, and mouse models.
• Conduct genetic barcoding, lineage tracing, and functional genomics studies.
• Contribute to manuscripts, grant applications, and mentoring activities.

Skills

Independent work

Collaborative work

Molecular biology

Mammalian cell culture

Education

Ph.D. in Cancer Biology or related field

Job description

Research Focus

Our research aims to uncover the molecular mechanisms that govern cancer cell behavior by focusing on:

• Functional heterogeneity within tumors
• Phenotypic plasticity during tumor evolution and therapy response
• Cellular competence in tumor initiation, adaptation, and drug resistance

Rather than simply cataloging cellular states, we seek to identify the mechanisms that establish, maintain, and regulate them. We combine genetic barcoding-based lineage tracing, functional genomics, organoid and mouse models, CRISPR perturbations, and single-cell multiomics to track cancer evolution at clonal resolution and uncover causal regulators of cancer cell identity and behavior.

The laboratory includes both experimental and computational researchers, fostering a collaborative and interdisciplinary approach to studying cancer evolution and cell-state dynamics.

Current Research Areas

• Cellular competence and tumor evolution
• Phenotypic plasticity, memory, and adaptation
• Developmental programs and cancer cell states

Responsibilities

• Design and execute independent research projects.
• Perform experiments using organoid, cell culture, and mouse models.
• Conduct genetic barcoding, lineage tracing, and functional genomics studies.
• Contribute to manuscripts, grant applications, and mentoring activities.

Qualifications

Required

• Ph.D. in Cancer Biology, Molecular Biology, Genetics, Epigenetics, Stem Cell Biology, or a related field.
• Strong publication record or evidence of research productivity.
• Ability to work independently and collaboratively.
• Experience with molecular biology and mammalian cell culture.

Preferred

Experience in one or more of the following:

• Organoids or mouse models
• Genetic barcoding, clonal tracking, and lineage tracing
• Single-cell genomics and multiomics
• ATAC-seq, RNA-seq, CUT&Tag, or CUT&RUN
• CRISPR technologies

What We Offer

Join an NIH-funded laboratory and help shape an ambitious research program at the intersection of cancer biology, epigenetics, stem cell biology, and genomics. Trainees will receive close mentorship, access to state-of-the-art technologies, and strong support for career development and scientific independence.

Mount Sinai is an equal opportunity employer, and we encourage applications from individuals of all backgrounds. We value diversity and inclusion in our research community.

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