Postdoctoral Fellow-MSH-30025-253

Mount Sinai; United States; On-site; USD 75,000 - 80,000; Full time

Job summary

The Mzoughi lab at Icahn School of Medicine at Mount Sinai in New York City is seeking a highly motivated Post-Doctoral Researcher or Scientist to join the team. You will design and execute experiments to characterize cell state dynamics and the mechanisms driving cancer evolution, focusing on functional epigenetics and cancer evolution, working with wet and dry lab members and the PI Dr.

Mzoughi to develop strategies to reverse aberrant cell states.

Qualifications

• Ph.D. in a relevant field (e.g., cancer biology, molecular biology, (epi)genetics, or related disciplines).
• At least one first-author publication in a reputable journal.
• Proficiency in basic molecular biology techniques, including DNA/RNA extraction, PCR, qPCR, cloning, and western blotting.
• Preferred experience in ATAC-seq, ChIP-seq, RNA-seq, and/or working with organoids, mice, and genetic barcoding.
• Excellent organizational skills and attention to detail.
• Ability to work independently as well as collaboratively in a team-oriented environment.
• Effective communication and interpersonal skills.

Responsibilities

• Culture normal and cancer organoid models.
• Conduct genetic barcoding and lineage tracing experiments.
• Perform drug screens.
• Maintain and report accurate records of data.
• You will have the opportunity to be trained in bulk and single-cell genomics techniques, such as ATAC-seq, RNA-seq, and CUT&Tag.

Skills

Molecular biology

Genomics

Communication

Teamwork

Education

Ph.D. in a relevant field

Tools

ATAC-seq

ChIP-seq

RNA-seq

Single-cell genomics

Job description

Location

Icahn School of Medicine at Mount Sinai, New York City

The Mzoughi Lab focuses on

1. Dissecting the epigenetic mechanisms underlying phenotypic heterogeneity and plasticity by integrating lineage tracing with cutting-edge multiomics technologies.
2. Investigating the relationship between tumor behavior and their developmental origins through a combination of computational modeling and experimental approaches.

We are seeking a highly motivated and skilled Post-Doctoral Researcher or Scientist to join our team. This position offers an exciting opportunity to contribute to cutting-edge research in functional epigenetics and cancer evolution. As a key member of our team, you will play a crucial role in designing and executing experiments to characterize cell state dynamics and the underlying mechanisms during cancer evolution.

The successful candidate will work closely with wet and dry lab team members and the Principal Investigator (Dr. Mzoughi) to develop innovative strategies to reverse aberrant cell states in cancer. Staying abreast of the latest advancements in the field of epigenetic plasticity and high impact publications are also expected.

Our group collaborates closely with the Techno-Omics Research unit, embedded within the Center for Oncogenomics and Innovative Therapeutics, to develop new single-cell omics tools.

Key Responsibilities

• Culture normal and cancer organoid models .
• Conduct genetic barcoding and lineage tracing experiments.
• Perform drug screens.
• Maintain and report accurate records of data.
• You will have the opportunity to be trained in bulk and single-cell genomics techniques, such as ATAC-seq, RNA-seq, and CUT&Tag.

Requirements

• Ph.D. in a relevant field (e.g., cancer biology, molecular biology, (epi)genetics, or related disciplines).
• At least one first-author publication in a reputable journal.
• Proficiency in basic molecular biology techniques, including DNA/RNA extraction, PCR, qPCR, cloning, and western blotting.
• Preferred experience in ATAC-seq, ChIP-seq, RNA-seq, and/or working with organoids, mice, and genetic barcoding.
• Excellent organizational skills and attention to detail.
• Ability to work independently as well as collaboratively in a team-oriented environment.
• Effective communication and interpersonal skills.

The Mzoughi lab is dedicated to transformative basic and translational research aimed at improving cancer treatment and patient outcomes. By joining our young team, you will have the unique opportunity to work alongside dedicated researchers and clinicians who share a passion for making a meaningful impact in the field of oncology.

Mount Sinai is an equal opportunity employer, and we encourage applications from individuals of all backgrounds. We value diversity and inclusion in our research community.

Note: Only shortlisted candidates will be contacted for an interview.

Compensation Statement

The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $74,692.00 - $80,000.00 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.

SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 824 - Oncological Sciences - ISM, Icahn School of Medicine