Postdoctoral Fellow: Lysosome Biology & Multimodal Imaging

University of Michigan; Ann Arbor (MI); On-site; USD 55,000 - 75,000; Full time

Benefits offered by this job

Health insurance

Dental and Vision Insurance

Life insurance

Flexible spending accounts

Maternity and Parental Leave

Job summary

The University of Michigan Life Sciences Institute invites a postdoctoral fellow to apply multimodal imaging workflows and multi-omics analyses to lysosomal biology. You will conduct imaging, proteomics, and organoid work onsite and collaborate with the Mosalaganti lab.

Candidate should have a PhD in cell biology or related field, strong microscopy, and omics experience, with independence and teamwork to advance brain biology research.

Qualifications

• Ph.D. in cell biology, neurobiology, genetics, or related discipline.
• Minimum of 2 years of experience with light and confocal microscopy (imaging/data processing).
• Minimum of 2 years of experience with primary cultures or stem cells.
• Familiarity with CRISPR/Cas9 and molecular biology/cloning.
• 2 years of experience in analyzing 'omics' datasets.
• Ability to work independently and as a team player.

Responsibilities

• Identifying and characterizing proteins responsible for lysosomal susceptibility and resilience in models of neurodegeneration.
• Conduct biochemical assays including western blot, transcriptomics, immunoprecipitation of proteins and organelles (e.g., lysosomes), quantitative proteomics analyses, fluorescence microscopy, and in vivo / in vitro enzyme assays.
• Maintain and amplify iPSC-derived neurons, microglia, and astrocytes and analyze physiological and biochemical data from brain tissue samples.
• Generate brain organoids and assembloids.
• Work with PI to apply for independent research funding.
• Mentor undergraduates and graduate students in the laboratory.
• Assist PI with writing manuscripts and grants.

Skills

Microscopy

Cell culture

CRISPR/Cas9

Omics analyses

Independent researcher

Education

Ph.D. in cell biology or neurobiology

Tools

CRISPR/Cas9 tools

Job description

The University of Michigan Life Sciences Institute invites a postdoctoral fellow to apply multimodal imaging workflows and multi-omics analyses to lysosomal biology. You will conduct imaging, proteomics, and organoid work onsite and collaborate with the Mosalaganti lab.

Candidate should have a PhD in cell biology or related field, strong microscopy, and omics experience, with independence and teamwork to advance brain biology research.