Postdoctoral Fellow - Krainer Lab

Cold Spring Harbor Laboratory; Cold Spring Harbor (NY); On-site; USD 60,000 - 80,000; Full time

Job summary

Cold Spring Harbor Laboratory in New York seeks a Postdoctoral Fellow to join a pioneering program focused on mechanistic dissection of a neurodevelopmental disorder and preclinical ASO therapeutics development. The role blends RNA biology, genetics, and translational research in a collaborative setting.

The successful candidate will establish mouse models, analyze transcriptomes, and explore splicing defects while developing RNA-targeted therapies and collaborating across multidisciplinary

Qualifications

• Ph.D. in a relevant field with a strong publication record.
• Experience with RNA analysis, gene expression, or RNA-protein interaction studies.
• Excellent analytical, organizational, and communication skills; able to work independently and in teams.

Responsibilities

• Establish and characterize mouse models with the Engineered Mouse Model Core Facility.
• Evaluate transcriptome perturbations using sequencing, RT-PCR, and qPCR.
• Characterize mouse neurodevelopmental phenotypes with a behavioral scientist’s input.
• Investigate structure–function relationships using disease-causing missense mutants and functional assays.
• Identify downstream splicing/expression changes and develop ASOs to restore normal expression.
• Analyze data and communicate findings via presentations, publications, and grants.
• Collaborate with teams in RNA biology, ASO therapeutics, and translational research.
• Mentor junior lab members and contribute to a collaborative environment.

Skills

Analytical skills

Organizational skills

Communication skills

Independent & collaborative work

Education

Ph.D. in Molecular Biology/Genetics/Biochemistry/RNA Biology/Neuroscience/Pharmacology or related field

Tools

Next-generation sequencing

Job description

Position Description

The laboratory of Dr. Adrian Krainer at Cold Spring Harbor Laboratory is seeking a highly motivated Postdoctoral Fellow to join an innovative research program and advance a research project focused on mechanistic dissection of a neurodevelopmental genetic disorder and preclinical development of antisense oligonucleotide (ASO) therapeutics.

The successful candidate will lead and contribute to a project investigating a genetic neurodevelopmental disorder that affects an RNA-binding protein involved in mRNA splicing. The project aims to characterize the genetic mechanisms of the disorder and the resulting splicing dysfunction, and to establish appropriate mouse models, with the ultimate goal of developing an RNA-targeted therapy.

This position offers the opportunity to work at the intersection of RNA biology, genetics, neurology, and ASO therapeutics development in a highly collaborative and translational research environment.

Position Responsibilities

• Establish and characterize mouse models, with the help of our Engineered Mouse Model Core Facility.
• Evaluate transcriptome perturbations using next-gen sequencing analysis, RT-PCR, and qPCR.
• Characterize mouse neurodevelopmental phenotypes, with expert advice from a behavioral neuroscientist.
• Investigate structure-function relationships using disease-causing missense mutants and a variety of cell-based and biochemical functional assays.
• Identify key downstream alternative splicing or expression changes as potential therapeutic targets, and develop appropriate ASOs to restore normal expression.
• Analyze and interpret experimental data and communicate findings through presentations, publications, and grant reports.
• Collaborate with multidisciplinary teams working in RNA biology, ASO therapeutics, and translational research.
• Mentor junior laboratory members as appropriate, and contribute to a collaborative research environment.

Position Requirements

• Ph.D. in Molecular Biology, Genetics, Biochemistry, RNA Biology, Neuroscience, Pharmacology, or a related field.
• Strong record of scientific achievement demonstrated through peer-reviewed publications.
• Experience with molecular-biology techniques, including RNA analysis, gene-expression, and/or RNA-protein interaction studies.
• Excellent analytical, organizational, and communication skills.
• Ability to work independently and collaboratively in a fast-paced research environment.

Preferred

• Experience with antisense oligonucleotides, RNA therapeutics, alternative splicing, or RNA biology.
• Experience working with mouse models of disease.
• Experience with next-generation sequencing and bioinformatic analysis.

Supplemental Information

Research Environment

The Krainer laboratory is internationally recognized for pioneering discoveries in RNA biology, alternative splicing, and the preclinical development of RNA-targeted therapeutics for neurodegenerative disorders and cancer. The successful candidate will have access to state-of-the-art facilities and a collaborative scientific community dedicated to exploring biological mechanisms and advancing innovative treatments for human disease.

Environment

Cold Spring Harbor Laboratory is a world-renowned biomedical research institution in New York. It has shaped contemporary biomedical research and is the home of eight Nobel Prize laureates. Cold Spring Harbor Laboratory provides a highly dynamic and interactive research environment and also a unique opportunity of timely exposure to advances in various biomedical research fields and of interaction with a broad range of researchers from all over the world through its renowned Meetings and Courses program. We believe that science is for everyone and our researchers have a wide variety of backgrounds.

Compensation And Benefits

Our employees are compensated in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, paid time off, and a range of recognition and wellness programs. Visit our CSHL The salary range or hourly rate listed is a good faith determination of potential base compensation that may be offered to a successful applicant for this position at the time of this job advertisement and may be modified in the future. When determining a base salary and/or rate, several factors may be considered as applicable (e.g., years of relevant experience, education, credentials, and internal equity).

CSHL is an EO Employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, or protected veteran status. VEVERAA Federal Contractor

CSHL Postdoctoral Fellows are compensated in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, padi time off, relocation reimbursement, a Wellness Center and access to an affordable and licensed on-site childcare center. Visit our