Postdoctoral Fellow: HIV-1 Vaccine Immunology & B Cells

Dana-Farber Cancer Institute (DFCI); Boston (MA); On-site; USD 72,000 - 76,000; Full time

Job summary

Dana-Farber Cancer Institute in Boston invites applications for a Postdoctoral Research Fellow in the Reinherz Lab to study HIV-1 vaccine immunology using structural biology, molecular biology, biochemistry, and immunology.

The candidate will contribute to HIV-1 Env vaccine design, B cell affinity maturation studies, and structure-guided immunogen development, with opportunities for independent project leadership and manuscript preparation.

Qualifications

• Recent PhD or MD/PhD in biomedical sciences or a closely related field.
• Strong background in immunology, molecular biology, and biochemistry.
• Hands-on experience with immune response assessment including antibody measurement and B/T cell analysis.
• Experience with mouse models and animal handling.
• Demonstrated publication record in peer-reviewed journals.
• Excellent written and verbal communication skills.
• Ability to work independently as well as collaboratively in a team.

Responsibilities

• Design and execute studies related to HIV-1 Env vaccine candidates.
• Investigate approaches to enhance B cell affinity maturation and antibody responses.
• Perform mouse immunization studies and related in vivo experiments.
• Analyze immune sera to assess vaccine-elicited responses.
• Conduct flow cytometry (FACS) for immune cell characterization and analysis.
• Perform B cell repertoire analysis and immunohistology experiments.
• Carry out molecular cloning, protein expression, and protein purification.
• Maintain and utilize cell culture systems to support research activities.
• Interpret experimental data, prepare reports, and contribute to manuscripts for publication.
• Collaborate effectively with lab members and support broader research goals.

Skills

Immunology

Molecular biology

Biochemistry

Written communication

Independent work

Team collaboration

Education

PhD or MD/PhD in biomedical sciences

Tools

Molecular cloning

Protein expression

Protein purification

Cell culture

Job description

Dana-Farber Cancer Institute in Boston invites applications for a Postdoctoral Research Fellow in the Reinherz Lab to study HIV-1 vaccine immunology using structural biology, molecular biology, biochemistry, and immunology.

The candidate will contribute to HIV-1 Env vaccine design, B cell affinity maturation studies, and structure-guided immunogen development, with opportunities for independent project leadership and manuscript preparation.