Postdoctoral Fellow: Cellular Pharmacology & Assay Innovation

Georgia Institute of Technology; Atlanta (GA); On-site; USD 60,000 - 90,000; Full time

Job summary

Georgia Tech’s School of Biological Sciences seeks a Postdoctoral Fellow in Cellular Pharmacology to support target validation, mechanism-of-action studies, and small-molecule characterization across drug discovery programs.

The role involves mammalian cell culture, assay development, and applying advanced techniques like NanoBRET/NanoBiT to measure target engagement, with collaboration across multidisciplinary teams. Prior experience in 3D models is a plus.

Qualifications

• PhD in Biochemistry, Biophysics, Enzymology, Chemical Biology, or a related discipline.
• Excellent problem-solving, data analysis, organizational, and communication skills.
• Ability to work independently while contributing effectively within interdisciplinary teams.

Responsibilities

• Perform routine mammalian cell culture, maintenance, expansion, and generation of engineered cell lines.
• Design and execute cellular pharmacology studies, including dose-response, time-course, washout, proliferation, viability, and pathway modulation assays.
• Develop and apply NanoBRET, NanoBiT, and related approaches to assess target engagement and protein-protein interactions.
• Conduct western blotting, immunofluorescence, microscopy, and protein localization studies.
• Analyze and interpret experimental data, optimize assays, troubleshoot challenges, and maintain accurate records.
• Collaborate with multidisciplinary teams and communicate findings through presentations and publications.
• Know-how on advanced cellular models, including 3D cultures and organoids, is desirable.

Skills

Recombinant protein production

Enzymology

Assay development

Biophysical characterization

Problem-solving

Data analysis

Organizational skills

Communication skills

Independent work

Team collaboration

Education

PhD in Biochemistry, Biophysics, Enzymology, Chemical Biology, or related discipline

Job description

Georgia Tech’s School of Biological Sciences seeks a Postdoctoral Fellow in Cellular Pharmacology to support target validation, mechanism-of-action studies, and small-molecule characterization across drug discovery programs.

The role involves mammalian cell culture, assay development, and applying advanced techniques like NanoBRET/NanoBiT to measure target engagement, with collaboration across multidisciplinary teams. Prior experience in 3D models is a plus.