Postdoctoral Fellow - Cellular Pharmacology

Georgia Institute of Technology; Atlanta (GA); On-site; USD 58,000 - 72,000; Full time

Job summary

Georgia Tech in Atlanta seeks a Postdoctoral Fellow in Cellular Pharmacology to support target validation, mechanism-of-action studies, and small-molecule characterization across drug discovery programs.

The Skolnick Group aims to advance cellular pharmacology using mammalian systems, with emphasis on target engagement and pathway analysis. Excellent hands-on laboratory skills and independent work are essential.

Qualifications

• PhD in Biochemistry, Biophysics, Enzymology, Chemical Biology, or a related discipline.
• Strong hands-on experience in recombinant protein production, enzymology, assay development, and biophysical characterization.
• Excellent problem-solving, data analysis, organizational, and communication skills.
• Ability to work independently while contributing effectively within interdisciplinary teams.

Responsibilities

• Perform routine mammalian cell culture, maintenance, expansion, and generation of engineered cell lines.
• Design and execute cellular pharmacology studies, including dose-response, time-course, washout, proliferation, viability, and pathway modulation assays.
• Develop and apply NanoBRET, NanoBiT, and related approaches to assess target engagement and protein-protein interactions.
• Conduct western blotting, immunofluorescence, microscopy, and protein localization studies.
• Analyze and interpret experimental data, optimize assays, troubleshoot challenges, and maintain accurate records.
• Collaborate with multidisciplinary teams and communicate findings through presentations and publications.
• Know-how on advanced cellular models, including 3D cultures and organoids, is desirable.

Skills

Mammalian cell culture

Dose–response assays

Data analysis

Scientific communication

Education

PhD in Biochemistry/Biophysics/Enzymology/Chemical Biology

Tools

NanoBRET

Job description

Georgia Tech in Atlanta seeks a Postdoctoral Fellow in Cellular Pharmacology to support target validation, mechanism-of-action studies, and small-molecule characterization across drug discovery programs.

The Skolnick Group aims to advance cellular pharmacology using mammalian systems, with emphasis on target engagement and pathway analysis. Excellent hands-on laboratory skills and independent work are essential.