Postdoc- Spatial and Organelle Proteomics in Brain Aging and Neurodegeneration

AlzForum Foundation Inc.; Jacksonville (FL); On-site; USD 55,000 - 75,000; Full time

Job summary

Mayo Clinic in Jacksonville, Florida, is seeking postdoctoral researchers in neuroscience to investigate molecular and cellular mechanisms of brain aging and neurodegenerative diseases. Projects emphasize spatial and organelle-resolved proteomics and ubiquitinomics in human autopsy brain, complemented by molecular biology, biochemistry, and advanced imaging.

The successful candidate will work in a collaborative neuroscience environment, with opportunities to develop independent directions within

Qualifications

• Recent PhD in neuroscience, cell or molecular biology, biochemistry, biomedical sciences, or a related discipline.
• Strong background in neurodegeneration, proteomics, imaging, or iPSC-based models.
• Excellent communication, productivity, and collaboration abilities.

Responsibilities

• Investigate molecular and cellular mechanisms of brain aging and neurodegenerative diseases.
• Perform spatial and organelle-resolved proteomics and related analyses in human brain samples.

Skills

Neurodegeneration

Protein aggregation

Ubiquitin signaling

Mitochondrial biology

Lysosomal biology

Molecular neuroscience

Cell biology

High resolution proteomics

Advanced imaging

iPSC-derived models

In vivo disease models

Education

PhD or equivalent doctoral degree

Job description

Postdoc - Spatial and Organelle Proteomics in Brain Aging and Neurodegeneration

The Springer Laboratory in the Department of Neuroscience at Mayo Clinic in Jacksonville, Florida, is seeking highly motivated postdoctoral research fellows to investigate molecular and cellular mechanisms underlying brain aging and neurodegenerative diseases.

Current projects focus on spatial and organelle-resolved proteomics as well as ubiquitinomics in human autopsy brain to define cellular and subcellular changes associated with Alzheimer’s or Parkinson’s disease and related dementias. Proteomics will be complemented by molecular and cellular biology, biochemistry, and advanced imaging of brain, and in functional human iPSC-based and in vivo animal models.

The successful candidate will have the opportunity to develop an independent research direction within these funded programs and work in a highly collaborative neuroscience environment.

Requirements

Recent Ph.D. or equivalent doctoral degree in neuroscience, cell or molecular biology, biochemistry, biomedical sciences, or a related discipline.

Candidates should have a strong research background and demonstrated experience in one or more of the following areas: neurodegeneration, protein aggregation, ubiquitin signaling, mitochondrial and lysosomal biology, molecular and cellular neuroscience, high resolution proteomics, advanced imaging, iPSC-derived cell/organoid models, or in vivo disease models.

Strong scientific communication skills, a record of research productivity, and the ability to work both independently and collaboratively are expected.