Postdoc: Senescence, Aging & Inflammation with scRNA-seq

University of Pennsylvania; Philadelphia (Philadelphia County); On-site; USD 60,000 - 80,000; Full time

Job summary

The University of Pennsylvania invites applications for a Postdoctoral Fellow in Senescence, Aging and Inflammation in the Graves Laboratory at Penn Dental Medicine. The fellow will study how senescence and inflammatory signals affect aging-related pathology using periodontal mouse models and human tissue validation.

Responsibilities include leading bioinformatic analyses (scRNA-seq, Xenium spatial data), conducting in vivo and in vitro experiments, and integrating findings with imaging and

Qualifications

• PhD, MD, DMD, DVM or equivalent doctoral degree in a relevant field.
• Strong background in cell biology, molecular biology, immunology, skeletal biology, bioengineering, genomics, computational biology, bioinformatics, systems biology, or a related discipline.
• Demonstrated scientific rigor and ability to interpret findings in a biological context.
• Ability to work independently and collaborate across disciplines.
• Strong scientific writing, presentation, and communication skills.

Responsibilities

• Investigate molecular and cellular mechanisms linking senescence and inflammation to tissue dysfunction, repair, and regeneration using in vivo mouse models.
• Lead or contribute substantially to bioinformatic analyses of scRNA-seq and spatial transcriptomic datasets.
• Develop and execute rigorous experimental approaches using in vivo, ex vivo, and/or in vitro models as appropriate.
• Perform quality control, data integration, cell annotation, differential expression, pathway, trajectory, state-transition, and ligand–receptor analyses.
• Integrate transcriptomic findings with imaging, histologic, cellular, and phenotypic measurements.
• Use immunofluorescence and quantitative image analysis to characterize cellular localization and tissue organization.
• Develop robust, reproducible experimental and computational workflows.
• Interpret findings and contribute to analytical and experimental strategy.
• Generate figures, present findings, and communicate with collaborators.
• Prepare first-author manuscripts and contribute to grant development.

Skills

Scientific writing

Collaborative work

Independent working

Education

PhD/MD/DMD/DVM or equivalent

Tools

scRNA-seq

spatial transcriptomics

Job description

The University of Pennsylvania invites applications for a Postdoctoral Fellow in Senescence, Aging and Inflammation in the Graves Laboratory at Penn Dental Medicine. The fellow will study how senescence and inflammatory signals affect aging-related pathology using periodontal mouse models and human tissue validation.

Responsibilities include leading bioinformatic analyses (scRNA-seq, Xenium spatial data), conducting in vivo and in vitro experiments, and integrating findings with imaging and