Postdoc: Immune Genomics in Sjögren’s Disease

Office of Intramural Training & Education; Bethesda (MD); Presencial; USD 52.000 - 71.000; Jornada completa

Descripción de la vacante

NIH National Institute of Dental and Craniofacial Research in Bethesda, MD invites applications for a postdoctoral fellow in the Salivary Disorders Unit and Sjögren’s Disease Clinic.

The successful candidate will study immune-mediated salivary disorders using single-cell RNA sequencing, spatial transcriptomics, and immune-receptor profiling, with a focus on antigen discovery and T-cell interactions in patient-derived models.

Formación

• PhD in immunology or a closely related field is required.
• Strong experience with single-cell and spatial transcriptomics techniques is essential.
• Experience with antigen discovery and immune-receptor profiling is desirable.

Responsabilidades

• Define disease-associated immune responses using integrated single-cell transcriptomics, immune-receptor profiling, and spatial transcriptomics.
• Discover antigens de novo by applying cellular engineering to patient-derived T-cell receptors.
• Investigate cellular interactions in situ using patient-derived organotypic cultures and assess antigen-driven inflammation and gland dysfunction.

Conocimientos

Single-cell transcriptomics

Immune profiling

Spatial transcriptomics

Cell engineering

T cell biology

Educación

PhD in Immunology or related field

Herramientas

Spatial transcriptomics platforms

Organoid culture

Descripción del empleo

NIH National Institute of Dental and Craniofacial Research in Bethesda, MD invites applications for a postdoctoral fellow in the Salivary Disorders Unit and Sjögren’s Disease Clinic.

The successful candidate will study immune-mediated salivary disorders using single-cell RNA sequencing, spatial transcriptomics, and immune-receptor profiling, with a focus on antigen discovery and T-cell interactions in patient-derived models.