Postdoc Scientist: Brain Aging HTS & iPSC Models

buckinstitute

Novato (CA)

On-site

USD 74,000 - 81,000

Full time

14 days+

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Benefits offered by this job

Health insurance

Parental leave

Childcare assistance

PTO and 401(k) with employer match

Job summary

The Buck Institute for Research on Aging invites applications for a Postdoctoral Researcher to lead a high-throughput screening (HTS) program focused on brain aging and neurodegeneration. You will develop and execute screens aiming to reverse aging phenotypes or build cellular resilience in neuronal models, integrating chemical biology with iPSC-based disease modeling and advanced high-content imaging.

You will work with robotic automation, analyze imaging data using Python and R, publish

Qualifications

PhD in Neuroscience, Biology, Chemistry, Chemical Biology, or a related field.
Hands-on HTS assay development experience and laboratory automation platforms.

Responsibilities

Develop and lead a high-throughput screening (HTS) effort to identify small molecules that reverse aging or build resilience, focusing on OXR1 and APOE2 biology.
Design and execute high-content imaging workflows and Cell Painting-based phenotypic profiling.
Develop and apply iPSC-derived neuronal and organoid models for disease-relevant screening.
Operate and integrate complex robotic automation platforms and multi-instrument workflows.
Analyze complex imaging outputs using Python and R; apply pathway analysis and data visualization tools.
Collaborate with biologists across the Buck Institute to standardize protocols and experimental design.
Contribute to peer-reviewed publications as a leading author and apply for fellowship/grant funding.
Participate in institutional seminars, programs, and the Buck Institute scientific community.