Postdoctoral Researcher - Brain Aging HTS & iPSC Models

Buck Institute; Novato (CA); On-site; USD 73,760 - 81,440; Full time

Benefits offered by this job

Health insurance

Parental leave

Childcare assistance

Paid time off

401(k) with match

Job summary

The Buck Institute for Research on Aging in Novato, CA seeks a Postdoctoral Researcher to lead an HTS program focused on brain aging and neurodegeneration. The successful candidate will develop screens to identify small molecules that reverse aging phenotypes and boost neuronal resilience, using iPSC-derived neurons and organoids.

You will work with robotic automation, run high-content Cell Painting workflows, and analyze imaging data with Python and R, collaborating across the Buck Institute to

Qualifications

• PhD in Neuroscience, Biology, Chemistry, Chemical Biology, or a related field.
• Hands-on experience with HTS assay development and laboratory automation platforms.
• Experience with high-content imaging and analysis pipelines (CellProfiler, Columbus, or similar).
• Proficiency in Python and/or R for image and data analysis.
• Demonstrated ability to drive independent research and a strong publication record.

Responsibilities

• Develop and lead a high-throughput screening (HTS) effort to identify small molecules that reverse aging to a youthful state or build resilience, with a focus on OXR1 and APOE2 biology.
• Design and execute high-content imaging workflows and Cell Painting–based phenotypic profiling.
• Develop and apply iPSC-derived neuronal and organoid models for disease-relevant screening.
• Operate and integrate complex robotic automation platforms and multi-instrument workflows.
• Analyze complex imaging outputs using Python and R; apply pathway analysis and data visualization tools.
• Collaborate with biologists across the Buck Institute to standardize protocols and experimental design.
• Contribute to peer-reviewed publications as a leading author and apply for fellowship/grant funding.
• Participate in institutional seminars, programs, and the Buck Institute scientific community.

Skills

HTS assay development

Lab automation platforms

High-content imaging

Python

R

Publication record

Independent research

Education

PhD in Neuroscience, Biology, Chemistry, Chemical Biology, or related field

Tools

CellProfiler

Columbus

Job description

The Buck Institute for Research on Aging in Novato, CA seeks a Postdoctoral Researcher to lead an HTS program focused on brain aging and neurodegeneration. The successful candidate will develop screens to identify small molecules that reverse aging phenotypes and boost neuronal resilience, using iPSC-derived neurons and organoids.

You will work with robotic automation, run high-content Cell Painting workflows, and analyze imaging data with Python and R, collaborating across the Buck Institute to