Postdoc Research Fellow

Construction Association of Michigan; Cleveland, Northern (OH, KY); Hybrid; USD 52,000 - 70,000; Full time

Job summary

Wenjian Gan Lab is seeking a full-time Postdoctoral Fellow to investigate mechanistic roles of post-translational modifications, focusing on arginine methylation in human cancers. You will map methylation pathways using biochemistry, cell biology, and organoid systems, and explore tumor progression with mouse models.

Responsibilities include executing experiments, co-authoring manuscripts, and contributing to translational efforts while maintaining lab operations and collaboration within the

Qualifications

• Ph.D. or M.D./Ph.D. in Biochemistry, Molecular/Cellular Biology, Cancer Biology, or related discipline.
• Hands-on expertise in molecular biology, protein biochemistry, cell culture techniques, and mouse models; organoid culture preferred.
• Track record of scientific productivity evidenced by peer-reviewed publications.
• Self-motivated, collaborative, organized, and driven to advance translational cancer research.

Responsibilities

• Execute biochemical and cell-based experiments to map arginine methylation pathways.
• Utilize genetic mouse models and patient-derived organoid platforms to study cancer progression and metastasis.
• Co-author manuscripts and grant applications; present findings in seminars.
• Contribute to daily lab operations and equipment maintenance.

Skills

Molecular biology

Protein biochemistry

Cell culture

Mouse models

Organoid culture

Education

Ph.D. or M.D./Ph.D.

Tools

IP/Western blot

PCR/RT-qPCR

Job description

A full-time Postdoctoral Fellow position is available in the Wenjian Gan Lab to investigate the mechanistic and physiological roles of protein post-translational modifications (PTMs)-with a focus on arginine methylation in human cancers. Research in the lab explores how arginine methylation regulates genomic instability, cell metabolism, signal transduction, and tumor progression to identify novel druggable targets. The project employs an integrative toolkit combining protein biochemistry, molecular biology, functional cell assays, genetic mouse models, and 3D patient-derived organoids (PDOs).

Key Responsibilities

• Molecular & Cellular Dissection: Execute biochemical and cell-based experiments (plasmid construction, PCR/RT-qPCR, transfections, IP/Western blot, proliferation, and colony formation assays) to map arginine methylation pathways.
• In Vivo & Translational Studies: Utilize genetic mouse models and patient-derived organoid platforms to study cancer progression and metastasis, including mouse breeding/genotyping, preclinical drug dosing, and tumor progression tracking.
• Scientific Communication & Grants: Co-author manuscripts and grant applications with the PI, create publication-ready figures, and present research findings in progress seminars and departmental journal clubs.
• Lab Stewardship: Contribute to daily laboratory operations, including equipment maintenance, reagent/buffer preparation, inventory management, and lab upkeep.

• Education & Experience: Ph.D. or M.D./Ph.D. in Biochemistry, Molecular/Cellular Biology, Cancer Biology, or a related discipline.
• Technical Skills: Proven hands-on expertise in molecular biology, protein biochemistry, cell culture techniques, and mouse models. Experience with organoid culture is preferred.
• Track Record: Strong background of scientific productivity evidenced by peer-reviewed publications.
• Professional Attributes: Self-motivated, collaborative, organized, and driven to advance translational cancer research.