Postdoctoral Fellow - Cancer Genetics and Epigenetics

City of Hope; Duarte (CA); On-site; USD 56,000 - 65,000; Full time

Job summary

City of Hope is seeking a highly motivated postdoctoral fellow in the laboratory of Dr. Yanzhong Yang within the Beckman Research Institute of City of Hope Cancer Center.

The role focuses on transcriptional regulation and RNA metabolism in development and disease, employing advanced molecular biology techniques. The candidate will work with CRISPR-based screens, single-cell transcriptomics, and genetically modified mouse models to explore arginine methylation's role in chromatin biology and RNA

Qualifications

• PhD in Biochemistry, Molecular and Cellular Biology, or related area.
• Strong interest in basic and translational research.
• Evidence of productivity reflected in first author publications in peer‑reviewed journals.
• Ability to conduct independent research and work effectively in a team.

Responsibilities

• Study transcriptional regulation and RNA metabolism in normal development and human diseases.
• Utilize CRISPR-based genomic screen, single-cell transcriptomics, and mouse models to investigate protein arginine methylation in chromatin biology, RNA splicing, and RNA modification.

Skills

Strong interest in research

Independent researcher

Team collaboration

Productivity track record

Education

PhD in Biochemistry or Molecular & Cellular Biology

Tools

CRISPR-based genomic screen

Single-cell transcriptomics

Job description

Join the forefront of groundbreaking research at City of Hope where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

The laboratory of Dr. Yanzhong Yang in the Department of Cancer Genetics and Epigenetics at the Beckman Research Institute of City of Hope Cancer Center is looking for a highly motivated postdoctoral fellow.

For more information about Dr. Yang lab, please visit here.

As a successful candidate you will:

• Study transcriptional regulation and RNA metabolism in normal development and human diseases, such as neurological disorder, immunology, and cancer.
• Utilize biochemistry, molecular biology, CRISPR-based genomic screen, single-cell transcriptomics, and genetically modified mouse models to investigate the role of protein arginine methylation in the regulation of chromatin biology, RNA splicing, and RNA modification in mammalian cells.

Your qualifications should include:

• A PhD in Biochemistry, Molecular and Cellular Biology, or related area.
• Strong interest in basic and translational research.
• Strong work ethic, meticulous and detail-oriented record keeping habits.
• Evidence of productivity reflected in first author publications in peer-reviewed journals.
• Ability to conduct independent research and work effectively in a team.
• The candidate should be self-motivated, with a proven track record of productivity.

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.