Postdoc: Host-Microbiome & Gut-on-Chip Biology

JAX; Farmington (CT); On-site; USD 66,000 - 76,000; Full time

Job summary

The Jalili lab at The Jackson Laboratory for Genomic Medicine in Farmington, CT invites applications for a Postdoctoral Fellow to study host–microbiome interactions using patient-derived colon organoids and advanced gut-on-a-chip systems.

The role focuses on epithelial biology, tissue engineering, and cancer-related mechanisms, with opportunities for interdisciplinary collaborations across CT and national partners.

Qualifications

• Ph.D. in bioengineering, microbiology, cell and molecular biology, cancer biology, or related field.
• Hands-on experience in cell and tissue engineering or 3D organoid culture.
• Experience with organ-on-a-chip or microfluidics is highly desirable.

Responsibilities

• Establish and maintain patient-derived intestinal organoids and integrate epithelia into microphysiological systems.
• Operate perfused, hypoxia-enabled gut-on-a-chip models to study epithelial function and host-microbiome interactions.
• Conduct controlled bacterial-epithelial coculture experiments to assess microbial influence on epithelial states and phenotypes.
• Apply microscopy, gene-expression analysis, and quantitative assays to study epithelial responses and molecular mechanisms.
• Integrate functional studies with transcriptomics to identify host pathways involved in regulation and disease susceptibility.

Education

Ph.D. in bioengineering or related field

Experience in organ-on-a-chip or microfluidics

Experience with gastrointestinal biology or host-microbiome research

Tools

Organ-on-a-chip

Microfluidics

Job description

The Jalili lab at The Jackson Laboratory for Genomic Medicine in Farmington, CT invites applications for a Postdoctoral Fellow to study host–microbiome interactions using patient-derived colon organoids and advanced gut-on-a-chip systems.

The role focuses on epithelial biology, tissue engineering, and cancer-related mechanisms, with opportunities for interdisciplinary collaborations across CT and national partners.