Postdoc: Gene Regulation & Single-Cell Multi-Omics Innovator

St. Jude Children's Research Hospital; Lauderdale Courts (TN); On-site; USD 52,000 - 70,000; Full time

Job summary

The Cheng Lab at St. Jude Children's Research Hospital seeks a Postdoctoral Research Associate to study gene regulation and genetic variation in human hematopoiesis and blood disorders.

We apply single-cell multi-omics, functional genomics, human genetics, computational biology, and genome engineering to map CREs and their disease relevance. Ideal candidates have a PhD and experience in single-cell genomics, regulatory biology, and computational genomics.

Qualifications

• PhD, MD/PhD, or equivalent degree in genetics, genomics, computational biology, bioinformatics, molecular biology, systems biology, hematology, computer science, or related fields.
• Experience in single-cell genomics, gene regulation/chromatin biology, computational genomics, human genetics, functional genomics, genome editing, or machine learning for genomic data is particularly relevant.
• Prior experience in sickle cell disease or erythroid biology is not required.

Responsibilities

• Integrating single-cell transcriptomic, epigenomic, and multi-omic data to understand gene regulation and cellular heterogeneity.
• Determining how genetic and structural variation alters cis-regulatory architecture and gene expression.
• Defining regulatory networks and genotype-to-phenotype relationships through computational genomics.
• Functionally testing regulatory elements and genetic variants using CRISPR-based genetic and epigenetic perturbation.
• Translating discoveries in gene regulation into new strategies for genome editing and genetic therapies.

Skills

Single-cell genomics

Computational biology

Genetic regulation

Data integration

Education

PhD in genetics/genomics or related field

Tools

CRISPR-based perturbation

Genome sequencing

Chromatin profiling

Multi-omics data integration

Job description

The Cheng Lab at St. Jude Children's Research Hospital seeks a Postdoctoral Research Associate to study gene regulation and genetic variation in human hematopoiesis and blood disorders.

We apply single-cell multi-omics, functional genomics, human genetics, computational biology, and genome engineering to map CREs and their disease relevance. Ideal candidates have a PhD and experience in single-cell genomics, regulatory biology, and computational genomics.