Postdoc: Single-Cell Gene Regulation & Genome Editing

St Jude Children's Research Hospital; Memphis (TN); On-site; USD 55,000 - 70,000; Full time

Job summary

The Cheng Lab at St. Jude Children's Research Hospital in Memphis seeks a highly motivated Postdoctoral Research Associate to investigate fundamental mechanisms of gene regulation and genetic variation in human hematopoiesis and blood disorders.

The successful candidate will integrate single-cell multi-omics, functional genomics, human genetics, computational biology, and genetic/epigenetic perturbation to understand CREs and disease associations.

Qualifications

• PhD/MD-PhD or equivalent degree in genetics, genomics, computational biology, bioinformatics, molecular biology, systems biology or related fields.
• Candidates with computational, experimental, or hybrid backgrounds are encouraged to apply.

Responsibilities

• Integrate single-cell transcriptomic, epigenomic, and multi-omic data to understand gene regulation and cellular heterogeneity.
• Determine how genetic and structural variation alters cis-regulatory architecture and gene expression.
• Define regulatory networks and genotype-to-phenotype relationships through computational genomics.
• Functionally test regulatory elements and genetic variants using CRISPR-based genetic and epigenetic perturbation.
• Translate discoveries in gene regulation into new strategies for genome editing and genetic therapies.

Skills

Single-cell genomics

CRISPR perturbation

Computational biology

Genetic regulation

Education

PhD/MD-PhD or equivalent

Job description

The Cheng Lab at St. Jude Children's Research Hospital in Memphis seeks a highly motivated Postdoctoral Research Associate to investigate fundamental mechanisms of gene regulation and genetic variation in human hematopoiesis and blood disorders.

The successful candidate will integrate single-cell multi-omics, functional genomics, human genetics, computational biology, and genetic/epigenetic perturbation to understand CREs and disease associations.