Postdoc Fellow: CRISPR Screens in HSCs for Genome Integrity

University of Pennsylvania Perelman School of Medicine; Pennsylvania; On-site; USD 60,000 - 70,000; Full time

Job summary

University of Pennsylvania Perelman School of Medicine invites applications for a postdoctoral fellow position in the Tong laboratory to study genome maintenance in hematopoietic stem cells. The project emphasizes CRISPR/Cas9 screening to identify druggable targets related to replication stress and DNA repair.

The work spans biochemistry, cell biology, and molecular biology with strong collaborations at CHOP and UPenn. Applicants with a Ph.D.

Qualifications

• Ph.D. or equivalent degree and experience in biochemistry, cell biology, and molecular biology.
• Experience with mouse models and genome integrity is preferred.

Responsibilities

• Perform state-of-the-art CRISPR/Cas9 screens to identify novel therapeutic targets.
• Study mechanisms safeguarding the genome during DNA replication in hematopoietic stem cells.
• Investigate how replication stress affects stem cell fitness and disease progression.

Skills

Biochemistry

Cell biology

Molecular biology

Mouse models

Education

Ph.D. or equivalent degree

Job description

University of Pennsylvania Perelman School of Medicine invites applications for a postdoctoral fellow position in the Tong laboratory to study genome maintenance in hematopoietic stem cells. The project emphasizes CRISPR/Cas9 screening to identify druggable targets related to replication stress and DNA repair.

The work spans biochemistry, cell biology, and molecular biology with strong collaborations at CHOP and UPenn. Applicants with a Ph.D.