Post-Doctoral Fellow - Fuglestad Lab

Wistar; Philadelphia (Philadelphia County); On-site; USD 54,000 - 72,000; Full time

Benefits offered by this job

Benefits package

Job summary

The Wistar Institute invites applications for a Post-Doctoral Fellow to join the laboratory of Dr. Brian Fuglestad in the Center for Advanced Therapeutics.

The project focuses on expanding molecular study of peripheral membrane proteins and developing new strategies for drug discovery. The fellow will advance hits to chemical probes and potential drug leads, with emphasis on synthesis and testing of inhibitor analogs.

Qualifications

• PhD in Chemistry, Medicinal Chemistry, or related field is required.
• Candidates should have at least one first-author peer-reviewed publication.
• Experience with synthetic or medicinal chemistry is required, with preference for biophysical or biochemical protein assays.

Responsibilities

• Advance initial screening hits to active chemical probes and toward drug leads.
• Iterative synthesis and testing of inhibitor analogs to inhibit peripheral membrane protein targets.
• Collaborate with biochemists and biophysicists to validate targets and assay systems.
• Contribute to project planning and interpretation of structure–activity relationships.

Skills

Synthetic chemistry

Medicinal chemistry

Biophysical assays

Biochemical assays

Education

PhD in Chemistry or Medicinal Chemistry

First-author publication

Job description

The Wistar Institute has an opening for a Post-Doctoral Fellow to join the laboratory of Dr. Brian Fuglestad as part of the Center for Advanced Therapeutics. The Fuglestad lab is interested in expanding molecular study of peripheral membrane proteins and enabling new strategies in drug development for this difficult category of protein. Their approach is rooted in detailed structural and biophysical investigation of fundamental protein function, information that is used to better understand peripheral membrane proteins as drug targets and to guide inhibitor design efforts. Their new approach opens a wide range of proteins and diseases to new therapeutic potential.

We are seeking a highly motivated Post-Doctoral Fellow to advance initial screening hits to active chemical probes for protein activity and towards drug leads. The project will involve iterative synthesis and testing of inhibitor analogs to achieve inhibition of peripheral membrane protein targets and potentially screening novel targets. The successful candidate will have experience with synthetic or medicinal chemistry, with a strong preference for candidates who also have experience with biophysical or biochemical protein assays.

A PhD in Chemistry, Medicinal Chemistry, or related fields is required. Candidates should have at least one first-author peer-reviewed publication.

We offer a competitive salary and excellent benefits package.

The Wistar Institute is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. Wistar provides resources for cutting-edge collaborative research and provides for outstanding intellectual environments and state-of-the-art facilities. The Wistar Institute is a world leader in early-stage discovery science in the areas of cancer, immunology, and infectious disease. Wistar is committed to accelerating research advances from bench to bedside through brilliant science and distinctive approaches to collaboration among scientific investigators and academic and industry partners. Wistar’s dynamic environment supports the advancement of discoveries that will change the future of human health.

For more information about The Wistar Institute visit our website at www.wistar.org.