Post-Doctoral Fellow - Wu Lab

Wistar Institute; Philadelphia (Philadelphia County); On-site; USD 60,000 - 68,000; Full time

Job summary

The Wistar Institute in Philadelphia invites applications for a Post-Doctoral Fellow to work at the intersection of molecular biology and bioinformatics, using single-cell multiomics to understand HIV reservoir epigenetics and latency reversal strategies.

The successful candidate will have a PhD in immunology, cell/molecular biology, or bioinformatics, strong wet-lab skills, experience with single-cell assays and NGS, and proficiency in Python/R; apply with CV, cover letter and references to Dr.

Qualifications

• PhD in immunology, cell/molecular biology, or bioinformatics required.
• Experience with single-cell assays and epigenetic assays is highly desirable.
• At least one first-author peer-reviewed publication.

Responsibilities

• Perform single-cell multiomics experiments to understand HIV reservoir epigenetics.
• Conduct tissue culture and molecular biology assays (PCR, qPCR, ddPCR).
• Apply bioinformatics analyses using Python/R in Unix environments.
• Contribute to manuscript preparation and collaborate with the Wu lab.

Skills

Single-cell multiomics

T cell immunology

Molecular biology

Tissue culture

PCR/qPCR/ddPCR

Next-generation sequencing

Bioinformatics (Python/R)

Unix systems

Education

PhD in immunology, cell/molecular biology, or bioinformatics

Tools

Unix

Python

R

Job description

The Wu laboratory started in December 2025 at The Wistar Institute and is focused on understanding the phenotypes of HIV infected cells and how they relate to proviral epigenetics for developing potent and specific latency reversal strategies. These strategies include the development of HIV DNA specific approaches with targeted mRNA-LNPs.

We are seeking a highly motivated Post-Doctoral Fellow to work at the intersection of molecular biology and bioinformatics by using single-cell multiomics to better understand the epigenetics of the HIV reservoir. The successful candidate will have experience with T cell immunology, extensive hands-on skills in basic tissue culture and molecular biology (PCR, qPCR, ddPCR, etc.), and next-generation sequencing. Strong expertise with single cell assays, epigenetic assays, and/or bioinformatics (familiarity with operating within Unix systems and experience with Python/R) is highly desirable.

A PhD in immunology, cell/molecular biology, or bioinformatics is required. Candidates should have at least one first-author peer-reviewed publication. In addition to the online application, interested individuals should apply by submitting a CV, one-page cover letter outlining the reason for their scientific interest in the lab and career goals, as well as names and contact information for at least 3 references to Dr. Vincent Wu,[e-mail].

We offer a competitive salary and excellent benefits package.

The Wistar Institute is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. Wistar provides resources for cutting-edge collaborative research and provides for outstanding intellectual environments and state-of-the-art facilities. The Wistar Institute is a world leader in early-stage discovery science in the areas of cancer, immunology, and infectious disease. Wistar is committed to accelerating research advances from bench to bedside through brilliant science and distinctive approaches to collaboration among scientific investigators and academic and industry partners. Wistar’s dynamic environment supports the advancement of discoveries that will change the future of human health.

For more information about The Wistar Institute visit our website atwww.wistar.org.

It is the policy of the Institute to provide equal employment opportunities to all individuals regardless of race, citizenship, ethnicity, color, creed, religion, marital status, national origin, ancestry, sex, age, veteran status, mental or physical disability (including HIV and AIDS), pregnancy, caregiver status, domestic or sexual violence victim status, sexual orientation, gender identity and expression, or on the basis of genetic information, or any other characteristic protected by federal, state, or local law, with respect to all terms and conditions of employment.