Associate Director: Translational Modeling & Simulation

Novartis Group Companies

Cambridge (MA)

Hybrid

USD 153,000 - 283,000

Full time

14 days+

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Job summary

Novartis Group Companies in Cambridge, MA is seeking an Associate Director in Translational Modeling to lead M&S strategies across programs, building mechanistic PK/PD, QSP, and PBPK/PD models that connect pharmacology to clinical outcomes.

You will collaborate with discovery, preclinical, clinical pharmacology, and pharmacometrics teams, mentor junior staff, and help shape dose selection and lifecycle management while embracing platform translational modeling initiatives.

Qualifications

Ph.D. in biology, bioengineering, pharmaceutical sciences, biophysics, or related field with 7+ years of industry experience.
Expert modeling skills in PK/PD, QSP, and PBPK/PD; pharmacometrics concepts (POP-PK, exposure-response) preferred.
Fluent in English (oral and written) with strong collaboration and communication skills.
Experience integrating computational modeling with biology concepts, and disease areas in neuroscience, cardiovascular, or metabolism; oligonucleotides/ADCs experience preferred.

Responsibilities

Act as M&S representative on multiple programs; develop and execute modeling strategies; guide decisions from design to first-in-human dose.
Build and apply mechanistic PK/PD, QSP, and PBPK/PD models linking pharmacology, tissue distribution, MOA, and downstream effects.
Integrate modeling into preclinical in vivo/in vitro study design and data interpretation to support candidate selection and progression.
Collaborate to develop platform-level translational models and workflows; contribute to platform initiatives across projects.
Mentor and provide strategic input within M&S; engage with broader Novartis platforms and initiatives.
Communicate modeling results to multidisciplinary audiences to influence strategy and decisions.