Oligonucleotide Therapeutics Scientist II

TALENT Software Services; South San Francisco (CA); On-site; USD 120,000 - 180,000; Full time

Job summary

TALENT Software Services seeks a Contractor/Scientist-II for the NADD team in the ProteinSciences department in South San Francisco. The role focuses on oligonucleotide discovery and synthesis to support new therapeutics initiatives.

Collaboration across neuroscience, immunology and oncology will be key. Ideal candidates have hands-on oligonucleotide synthesis, purification and characterization experience, plus a background in RNAi biology.

Qualifications

• Hands-on experience in oligonucleotide synthesis using automated oligo synthesizers.
• BS or MS in Organic Chemistry or related discipline.
• Experience in oligonucleotide purification and characterization using HPLC and mass spectrometry.
• Pharmaceutical/biotech R&D experience with RNAi therapeutics is a plus.

Responsibilities

• Work in an oligonucleotide therapeutic drug discovery lab interfacing across neuroscience, immunology and oncology.
• Collaborate to maintain lab equipment such as oligo synthesizers, HPLC, and desalting units.
• Propose and execute nucleic acid chemistry plans; coordinate chemistry and biology data.
• Establish methods for scaled-up synthesis of lead molecules and coordinate material delivery for preclinical studies.
• Maintain high productivity to meet timelines for in vitro and in vivo studies.

Skills

Oligonucleotide synthesis

HPLC & MS characterization

Collaborative team player

Education

BS/MS in Organic Chemistry

Tools

Oligonucleotide synthesizers

HPLC

Mass spectrometry

Job description

TALENT Software Services seeks a Contractor/Scientist-II for the NADD team in the ProteinSciences department in South San Francisco. The role focuses on oligonucleotide discovery and synthesis to support new therapeutics initiatives.

Collaboration across neuroscience, immunology and oncology will be key. Ideal candidates have hands-on oligonucleotide synthesis, purification and characterization experience, plus a background in RNAi biology.