Oligonucleotide Synthesis Ops Lead & Scientist

Alloy Therapeutics; Waltham (MA); On-site; USD 100,000 - 125,000; Full time

Benefits offered by this job

Equity compensation

401(k) company match

Unlimited PTO

Education stipend

Job summary

Alloy Therapeutics in Waltham, MA is seeking a Scientific Operations Manager / Associate Scientist to split time roughly 50/50 between running the NAC design-make-test workflow and bench chemistry. The role emphasizes building an operational backbone with strong process discipline and rigorous documentation across a growing genetic medicines program.

You will manage intake, scheduling, and KPI-driven dashboards, while also performing hands-on synthesis, purification, and analytical QC.

Qualifications

• Degree in chemistry/biochemistry or related field required.
• Hands-on synthesis, purification and analytical characterization experience.
• Experience with scheduling, demand planning or production operations is a plus.

Responsibilities

• Own end-to-end demand planning for NAC team and provide real-time status via dashboards.
• Design Tier Board system and track KPIs for on-time delivery and yield.
• Serve as Benchling admin, configure schemas and ensure traceability.
• Manage inventory and coordinate procurement for reagents and consumables.
• Ensure instrument readiness and plan preventive maintenance.
• Lead deviations, root-cause analysis and CAPA closure.
• Perform bench work: oligonucleotide synthesis, purification, QC, and data recording.
• Contribute to method development and technology transfer to scale production.

Skills

Solid-phase synthesis

Oligonucleotide QC

Benchling experience

Demand planning

Lean principles

CAPA investigations

Laboratory operations

Cross-functional collaboration

Education

Bachelor's degree in chemistry or related

Tools

Benchling

LIMS

HPLC/LC-MS

Automated synthesizers

Job description

Alloy Therapeutics in Waltham, MA is seeking a Scientific Operations Manager / Associate Scientist to split time roughly 50/50 between running the NAC design-make-test workflow and bench chemistry. The role emphasizes building an operational backbone with strong process discipline and rigorous documentation across a growing genetic medicines program.

You will manage intake, scheduling, and KPI-driven dashboards, while also performing hands-on synthesis, purification, and analytical QC.