Oligonucleotide Scientist II

TALENT Software Services; South San Francisco (CA); On-site; USD 120,000 - 160,000; Full time

Job summary

TALENT Software Services is seeking a Contractor/Scientist-II to join our Nucleic Acid Design and Discovery team in South San Francisco. The role focuses on oligonucleotide discovery and synthesis to support new therapeutics, with collaboration across RNAi biology and related drug discovery efforts.

The candidate will work in a chemistry lab interfacing with neuroscience, immunology, and oncology teams, contributing to a scalable synthesis plan and delivery for preclinical studies while

Qualifications

• BS/MS in Organic Chemistry or related field.
• Hands-on oligonucleotide synthesis experience.
• Experience with automated oligo synthesizers and purification.
• Familiarity with RNAi therapeutics and nucleic acid chemistry.

Responsibilities

• Work in an oligonucleotide therapeutic drug discovery lab.
• Collaborate across neuroscience, immunology, and oncology teams.
• Develop and execute nucleic acid chemistry plans.
• Establish scalable synthesis of lead molecules for preclinical studies.
• Maintain lab productivity to meet in vitro and in vivo study timelines.

Skills

Oligonucleotide synthesis

Automated oligo synthesizers

HPLC

Mass spectrometry

Nucleic acid chemistry

RNAi therapeutics understanding

Education

BS/MS in Organic Chemistry or related discipline

Tools

HPLC instrumentation

Mass spectrometry instrumentation

Job description

Working Model: Fully on-site, South San Francisco, CA

Working Days: Monday to Friday

Working Hours: Standard 8 hour shift

Interview Format: One Round (30 minutes) - Local candidates should join the interviews on site, candidates outside of the immediate area may join virtually.

The Position

We are seeking a creative, self-motivated, collaborative Contractor/Scientist-II to join the

Nucleic Acid Design and Discovery (NADD) team within ProteinSciences (PS) department at

We are looking for a candidate with experience in oligonucleotide discovery and

synthesis to support our new oligonucleotide therapeutics discovery group. Experience in

delivery of oligonucleotide therapeutics, large molecule drug discovery, would be preferred. The

successful candidate will join an interdisciplinary chemistry team working in RNAi biology

research and will contribute positively to its developing culture.

Key Responsibilities

• The candidate will work in an oligonucleotide therapeutic drug discovery research lab
• and interface across different therapeutic areas, including neuroscience, immunology
• and oncology, to help build a comprehensive therapeutic discovery strategy.
• Good understanding and also troubleshooting experience in oligonucleotide synthesis
• impurity profiling is a plus.
• Collaborate with other scientists to maintain common lab equipment such as oligo
• synthesizers, HPLC and desalt units.
• Perform literature reviews, propose, and execute nucleic acid chemistry plans
• coordinate chemistry and biology data to support oligonucleotide compound
• progression.
• Establish methods for scaled-up synthesis of lead molecules and coordinate material
• delivery for preclinical studies.
• Maintaining a high level of productivity in the laboratory setting to meet the timelines
• for in vitro and in vivo studies.

Requirements

• The candidate must have hands-on experience in oligonucleotide synthesis using
• automated oligo synthesizers, Client nucleic acid chemistry, oligonucleotide purification
• and characterization using HPLC and mass spectrometry.
• The qualified individual will possess a BS/MS in Organic Chemistry or related discipline.
• The pharmaceutical or biotechnology industry experience in research and development
• of RNAi therapeutics is preferred.
• A good understanding of nucleic acid therapeutic modalities, modification chemistries
• sequence selection, and mechanism of action is preferred. Relevant experience in
• oligonucleotide therapeutics, large molecule drug discovery, oligonucleotide delivery or
• bio-conjugation is desirable.
• Good communication and interpersonal skills are essential and will be evaluated during
• the interview process.
• The ideal candidate should be highly motivated and have strong problem-solving
• analytical, communication and organizational skills.