Scientist II (Oligonucleotide Synthesis)

Dawar Consulting, Inc.; South San Francisco (CA); On-site; USD 59,000 - 81,000; Full time

Benefits offered by this job

Medical

Dental

Vision

Paid Sick leave

401K

Job summary

Dawar Consulting, Inc. is seeking a Scientist II to advance oligonucleotide synthesis in South San Francisco, CA. This long-term contract role offers a $51/hr W2 rate and a comprehensive benefit package, including medical, dental, vision, and 401K.

The role focuses on discovery and development of RNAi-based therapeutics. Responsibilities include designing synthesis workflows, performing analytical characterization, and scaling lead candidates for preclinical studies while collaborating across

Qualifications

• BS/MS in Organic Chemistry or related field.
• Hands-on experience with oligonucleotide synthesis, purification, and characterization.
• Experience with automated oligo synthesizers, HPLC, and mass spectrometry.
• Understanding of RNAi, nucleic acid therapeutics, and modification chemistries preferred.

Responsibilities

• Design and execute oligonucleotide synthesis and purification workflows.
• Perform HPLC and mass spectrometer analysis for characterization and impurity profiling.
• Support RNAi and nucleic acid therapeutic discovery across neuroscience, immunology, and oncology programs.
• Develop and scale up synthesis of lead oligonucleotide candidates for pre clinical studies.
• Collaborate with cross-functional teams to integrate chemistry and biology data.
• Maintain and troubleshoot lab equipment (e.g., oligo synthesizers, HPLC systems).
• Conduct literature reviews and contribute to experimental design and strategy.

Skills

Hands-on oligonucleotide synthesis

Oligo purification

Oligo characterization

RNAi knowledge

Education

BS/MS in Organic Chemistry or related field

Tools

Automated oligo synthesizers

HPLC

Mass spectrometry

Job description

Scientist II (Oligonucleotide Synthesis)

South San Francisco, United States | Posted on 09/09/2026

Our client, a world leader in biotechnology and life sciences, is looking for anScientist II (Oligonucleotide Synthesis) based in South San Francisco, CA.

Job Duration:Long Term Contract(Possibility Of Extension)

Rate: $51/hr on W2

Company Benefits: Medical, Dental, Vision, Paid Sick leave, 401K

Overview

This role focuses onoligonucleotide therapeutics discovery, supporting RNAi-based research through synthesis, characterization, and collaboration across therapeutic areas.

Key Responsibilities

• Design and execute oligonucleotide synthesis and purification workflows.
• Perform HPLC and mass spectrometer analysis for characterization and impurity profiling.
• Support RNAi and nucleic acid therapeutic discovery across neuroscience, immunology, and oncology programs.
• Develop and scale up synthesis of lead oligonucleotide candidates for pre clinical studies.
• Collaborate with cross-functional teams to integrate chemistry and biology data.
• Maintain and troubleshoot lab equipment (e.g., oligo synthesizers, HPLC systems).
• Conduct literature reviews and contribute to experimental design and strategy.

Qualifications

• BS/MS in Organic Chemistry or related field.
• Hands-on experience with oligonucleotide synthesis, purification, and characterization.
• Experience with automated oligo synthesizers, HPLC, and mass spectrometry.
• Understanding of RNAi, nucleic acid therapeutics, and modification chemistries preferred.