Oligonucleotide Process Development Lead

Arrowhead Pharmaceuticals; Madison (WI); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Excellent benefits

Competitive salary

Job summary

Arrowhead Pharmaceuticals, Inc. in Madison, WI is seeking a Senior Scientist to lead a team of chemists in the development of scalable manufacturing processes for oligonucleotides.

The role is within the CMC Developmental Chemistry Department's Process Development organization. Responsibilities include scientific support for onsite manufacturing, design and implementation of process improvements, and development of synthesis and downstream processes to support candidates.

Qualifications

• PhD with 4+ years, or MS with 10+ years, or BS with 12+ years of industrial/academic experience in chemistry or related field.
• Direct experience with solid-phase oligonucleotide synthesis and downstream processes.
• Excellent verbal and written communication skills.
• Excellent problem-solving skills.
• Expertise in synthetic organic chemistry and relevant analytical technology.

Responsibilities

• Provide technical direction to a team of associate chemists engaged in oligonucleotide process development.
• Develop and optimize solid-phase oligonucleotide synthesis and downstream processes including cleavage, deprotection, purification, desalting, annealing, isolation, and bioconjugation.
• Provide technical review of batch records in support of upcoming manufacturing campaigns.
• Provide scientific and technical support to internal manufacturing team, including process troubleshooting and deviation investigation.
• Implement process improvements that enhance yield, purity, throughput, robustness, or safety.
• Plan and execute laboratory-scale studies, scale-up activities, and process characterization work with reproducible documentation.
• Collaborate with analytical development, manufacturing science and technology, quality, regulatory, and program management to align activities with objectives.
• Support technology transfer of newly developed processes from development into manufacturing.
• Utilize analytical techniques to characterize products and product-related impurities.
• Deliver multigram scale batches of siRNA and siRNA conjugates to support nonGMP activities.
• Demonstrate flexibility with changing priorities.

Skills

Solid-phase oligonucleotide synthesis

Downstream processes

Analytical techniques

Problem-solving

Excellent communication

Education

PhD in Chemistry or related field

MS in Chemistry or related field

BS in Chemistry or related field

Tools

Cytiva instrumentation

Unicorn software

OP100

Oligosynt

Avant

Job description

Arrowhead Pharmaceuticals, Inc. in Madison, WI is seeking a Senior Scientist to lead a team of chemists in the development of scalable manufacturing processes for oligonucleotides.

The role is within the CMC Developmental Chemistry Department's Process Development organization. Responsibilities include scientific support for onsite manufacturing, design and implementation of process improvements, and development of synthesis and downstream processes to support candidates.