mRNA Process Development Scientist

The RNA Society; Indiana (PA); On-site; USD 55,000 - 94,000; Full time

Job summary

NATi is seeking an Associate Scientist/Scientist, mRNA Process Development to advance vaccine and immunotherapy programs from discovery to IND-enabling stages. The role focuses on developing RNA workflows, purification, and analytical methods in a fast-paced, collaborative environment.

The candidate will contribute to SOPs, data integrity, and regulatory documentation while coordinating with CDMOs and internal teams. Based in Singapore with relocation support.

Qualifications

• BS or MS degree in Biochemistry, Molecular Biology, Biochemical Engineering, Pharmaceutical Sciences, or related field.
• Minimum of 4+ years (with MS) or 7+ years (with BS) in RNA Biochemistry or Pharmaceutical Sciences.
• Experience designing and conducting ex-vivo cell-based assays.
• Hands-on experience in ELISA, Western Blot, SDS-PAGE, and standard molecular biology/RNA biochemistry tools.
• Knowledge of nucleic acids purification tools (AEX, HIC, Affinity Chromatography, IP-RP HPLC) preferred.
• Proficiency with SnapGene, GraphPad Prism and Excel.
• Strong problem-solving and data analysis skills; able to work independently and in cross-functional teams.

Responsibilities

• Develop processes for synthesis of bacterial plasmid DNA, cell-free DNA and IVT mRNA for various RNA modalities.
• Develop purification methods for plasmid DNA, cell-free DNA and mRNA.
• Develop RNA characterization tools (CGE, HPLC, ELISA, cell-based expression, UV spectroscopy).
• Maintain SOPs and batch records for reproducibility and IND readiness.
• Maintain records using LIMS/ELN to support data integrity.
• Prepare technical reports and documents for internal decisions and regulatory submissions.
• Support tech transfer to external CDMOs, including training and troubleshooting.
• Assist regulatory submissions with CMC documentation.

Skills

ELISA

Western Blot

SDS-PAGE

PCR

RT-PCR

Cloning

Primer Design

RNA Purification

AEX

HIC

Affinity Chromatography

IP-RP HPLC

SnapGene

GraphPad Prism

Excel

LIMS/ELN

Problem Solving

Education

BS in Biochemistry / Molecular Biology / Biochemical Engineering / Pharmaceutical Sciences

MS in Biochemistry / Molecular Biology / Biochemical Engineering / Pharmaceutical Sciences

Tools

LIMS/ELN systems

SnapGene

GraphPad Prism

Excel

Job description

NATi is seeking an Associate Scientist/Scientist, mRNA Process Development to advance vaccine and immunotherapy programs from discovery to IND-enabling stages. The role focuses on developing RNA workflows, purification, and analytical methods in a fast-paced, collaborative environment.

The candidate will contribute to SOPs, data integrity, and regulatory documentation while coordinating with CDMOs and internal teams. Based in Singapore with relocation support.